Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates

被引:25
作者
Molinuevo, Jose L. [1 ,2 ,4 ]
Gomez-Anson, Beatriz [3 ]
Monte, Gemma C. [3 ]
Bosch, B. [1 ,2 ]
Sanchez-Valle, Raquel [1 ,2 ,4 ]
Rami, Lorena [1 ,2 ]
机构
[1] Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Dept Neurol, Inst Neurosci, E-08036 Barcelona, Spain
[2] Univ Barcelona, E-08036 Barcelona, Spain
[3] Hosp Santa Creu & Sant Pau, Neuroradiol Unit, Barcelona 08025, Spain
[4] Inst Invest Biomed August Pi & Sunyer, Barcelona 08036, Spain
关键词
Cognitive disorders; Neuropsychological tests; Dementia; Alzheimer's disease; Mild cognitive impairment; Magnetic resonance imaging; MILD COGNITIVE IMPAIRMENT; MEDIAL TEMPORAL ATROPHY; VOXEL-BASED MORPHOMETRY; DEMENTIA; CONVERSION; MRI; CLASSIFICATION; DISCRIMINATE; HIPPOCAMPAL; POPULATION;
D O I
10.1016/j.archger.2010.03.016
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
This study describes the cognitive profile of Prd-AD, the neuropsychological tests that may predict progression to dementia, and to study their brain structural correlates. We enrolled 24 stable amnesics who did not develop dementia after two years follow-up; 27 patients were considered as Prd-AD, in the initial visit, since they fulfilled NINCDS-ADRDA criteria after two years; 31 Alzheimer's disease (AD) patients and 27 controls (CTR). Structural magnetic resonance imaging (MRI), as well as a neuropsychological battery was performed at the initial visit. The key findings were: Prd-AD patients were characterized by prominent episodic memory dysfunction and minimal semantic memory and executive dysfunction. Semantic fluency test (Sem-Flu), delayed text memory test (Del-text-mem) and memory alteration test (M@T) (including both episodic and semantic memory), together with trail making test A (TMT-A), resulted significant predictors for dementia development in this group of amnesic patients. This optimal predictive model obtained an estimated accuracy of 53% after two years follow-up. M@T and semantic Sem-Flu test performance presented high correlation with decreased gray matter density in the left lateral temporal lobe. We conclude that Prd-AD is characterized by prominent episodic memory dysfunction and minimal semantic memory and executive dysfunction which are related with left medial, inferior and lateral temporal density loss, predominantly in the left side. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:190 / 196
页数:7
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