Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin

被引：33

作者：

Ferran, Aude ^{[1
]}

Dupouy, Veronique ^{[1
]}

Toutain, Pierre-Louis ^{[1
]}

Bousquet-Melou, Alain ^{[1
]}

机构：

[1] Ecole Natl Vet Toulouse, ENVT, INRA, UMR Physiopathol & Toxicol Expt 181, F-31076 Toulouse 3, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 11期

关键词：

D O I：

10.1128/AAC.00156-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate using an in vitro pharmacodynamic model that the likelihood of selection of Escherichia coli mutants resistant to a fluoroquinolone was increased when the initial size of the bacterial population, exposed to fluoroquinolone concentrations within the mutant selection window, was increased.

引用

页码：4163 / 4166

页数：4

共 10 条

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