Different Immunoregulation Roles of Activin A Compared With TGF-β

被引：16
|
作者：
Li, Fanglin [1 ,2 ]
Long, Yiru [1 ,2 ]
Yu, Xiaolu [1 ,2 ]
Tong, Yongliang [1 ,2 ]
Gong, Likun [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
activin A; TGF-beta; activin A signaling; macrophages; dendritic cells; B cells; T effector cells; regulatory T cells; GROWTH-FACTOR-BETA; REGULATORY T-CELLS; MACROPHAGES IN-VITRO; AUTOIMMUNE NEUROINFLAMMATION; ACTIVATION; CYTOKINE; SUPERFAMILY; TGF-BETA-1; PATHOGENICITY; MATURATION;
D O I：
10.3389/fimmu.2022.921366
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activin A, a critical member of the transforming growth factor-beta (TGF-beta) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-beta, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-beta.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] Targeting immunosuppression by TGF-β1 for cancer immunotherapy
    de Streel, Gregoire
    Lucas, Sophie
    BIOCHEMICAL PHARMACOLOGY, 2021, 192
  • [22] Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
    Sanjabi, Shomyseh
    Zenewicz, Lauren A.
    Kamanaka, Masahito
    Flavell, Richard A.
    CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (04) : 447 - 453
  • [23] Role of TGF-β in Melanoma
    Busse, A.
    Keilholz, U.
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2011, 12 (12) : 2165 - 2175
  • [24] Synergetic roles of TGF-β signaling in tissue engineering
    Kwak, Eun-A.
    Lee, Nam Y.
    CYTOKINE, 2019, 115 : 60 - 63
  • [25] Revisiting the regulatory roles of the TGF-β family of cytokines
    Fujio, Keshi
    Komai, Toshihiko
    Inoue, Mariko
    Morita, Kaoru
    Okamura, Tomohisa
    Yamamoto, Kauzhiko
    AUTOIMMUNITY REVIEWS, 2016, 15 (09) : 917 - 922
  • [26] TGF-β engineered mesenchymal stem cells (TGF-β/MSCs) for treatment of Type 1 diabetes (T1D) mice model
    Daneshmandi, Saeed
    Karimi, Mohammad Hossein
    Pourfathollah, Ali Akbar
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2017, 44 : 191 - 196
  • [27] TGF-β Regulation of T Cells
    Chen, WanJun
    ANNUAL REVIEW OF IMMUNOLOGY, 2023, 41 : 483 - 512
  • [28] Distinct signaling of drosophila Activin/TGF-β family members
    Gesualdi, Scott C.
    Haerry, Theodor E.
    FLY, 2007, 1 (04) : 212 - 221
  • [29] Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation
    Hedger, Mark P.
    Winnall, Wendy R.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 359 (1-2) : 30 - 42
  • [30] TGF-β Function in Immune Suppression
    Yoshimura, Akihiko
    Muto, Go
    NEGATIVE CO-RECEPTORS AND LIGANDS, 2011, 350 : 127 - 147
12345