Vitamin E in humans: Demand and delivery

被引：371
作者：
Traber, MG [1 ]
Sies, H [1 ]
机构：
[1] UNIV DUSSELDORF, INST PHYSIOL CHEM 1, D-40001 DUSSELDORF, GERMANY
来源：
ANNUAL REVIEW OF NUTRITION | 1996年 / 16卷
关键词：
tocopherol; lipoproteins; chylomicrons; VLDL; LDL; HDL; tocopherol transfer protein; ataxia with vitamin E deficiency;
D O I：
10.1146/annurev.nu.16.070196.001541
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms. The cause of vitamin E deficiency, characterized by peripheral neuropathy and ataxia, is usually malabsorption-a result of fat malabsorption or genetic abnormalities in lipoprotein metabolism. Genetic abnormalities in the hepatic alpha-tocopherol transfer protein also cause vitamin E deficiency-defects in this protein cause an impairment in plasma vitamin E transport. Impaired delivery of vitamin E to tissues, thereby, results in deficiency symptoms. Also discussed is the use of supplemental vitamin E in chronic diseases such as ischemic heart disease, atherosclerosis, diabetes, cataracts, Parkinson's disease, Alzheimer's disease, and impared immune function, as well as in subjects receiving total parenterol nutrition. In healthy individuals, a daily intake of about 15-30 mg of alpha-tocopherol is recommended to obtain ''optimal plasma alpha-tocopherol concentrations'' (30 mu M or greater).
引用
收藏
页码：321 / 347
页数：27
相关论文
共 158 条
[11]  
BENNER SE, 1994, CANCER EPIDEM BIOMAR, V3, P73
[12]   MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN STIMULATES MONOCYTE ENDOTHELIAL INTERACTIONS [J].
BERLINER, JA ;
TERRITO, MC ;
SEVANIAN, A ;
RAMIN, S ;
KIM, JA ;
BAMSHAD, B ;
ESTERSON, M ;
FOGELMAN, AM .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1260-1266
[13]  
BIESALSKI HK, 1995, DT ARZTEBL, V92, P1316
[14]   REDUCED HEPATIC ALPHA-TOCOPHEROL CONTENT AFTER LONG-TERM ADMINISTRATION OF ETHANOL TO RATS [J].
BJORNEBOE, GEA ;
BJORNEBOE, A ;
HAGEN, BF ;
MORLAND, J ;
DREVON, CA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 918 (03) :236-241
[15]  
BLANER WS, 1994, J BIOL CHEM, V269, P16559
[16]  
BLOMSTRAND R, 1968, INT Z VITAMINFORSCH, V38, P328
[17]   NUTRITION INTERVENTION TRIALS IN LINXIAN, CHINA - SUPPLEMENTATION WITH SPECIFIC VITAMIN MINERAL COMBINATIONS, CANCER INCIDENCE, AND DISEASE-SPECIFIC MORTALITY IN THE GENERAL-POPULATION [J].
BLOT, WJ ;
LI, JY ;
TAYLOR, PR ;
GUO, WD ;
DAWSEY, S ;
WANG, GQ ;
YANG, CS ;
ZHENG, SF ;
GAIL, M ;
LI, GY ;
YU, Y ;
LIU, BQ ;
TANGREA, J ;
SUN, YH ;
LIU, FS ;
FRAUMENI, JF ;
ZHANG, YH ;
LI, B .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (18) :1483-1492
[18]  
BOSCOBOINIK D, 1991, J BIOL CHEM, V266, P6188
[19]  
BOSTICK RM, 1993, CANCER RES, V53, P4230
[20]   VITAMIN-E IN HUMAN LOW-DENSITY-LIPOPROTEIN - WHEN AND HOW THIS ANTIOXIDANT BECOMES A PROOXIDANT [J].
BOWRY, VW ;
INGOLD, KU ;
STOCKER, R .
BIOCHEMICAL JOURNAL, 1992, 288 :341-344
12345678910