Copper(II)-catalyzed enantioselective intramolecular carboamination of alkenes

被引：221

作者：

Zeng, Wei ^{[1
]}

Chemler, Sherry R. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 43期

关键词：

D O I：

10.1021/ja0762240

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective oxidative cyclizations of gamma-alkenyl arylsulfonamides and a delta-alkenyl arylsulfonamide for the synthesis of nitrogen heterocycles are presented. The reactions are catalyzed by chiral copper(II) complexes, and MnO2 is used as the inexpensive stoichiometric oxidant. A variety of five-membered heterocycles and a tetrahydroisoquinoline have been synthesized in good to excellent yields with good to excellent levels of enantioselectivity. This is the first reported copper-catalyzed enantioselective carboamination of alkenes.

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页码：12948 / +

页数：3

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