Ischemic neuronal damage - How does mild hypothermia modulate it?

被引：7
作者：
Kataoka, K
Mitani, A
Yanase, H
Zhang, L
Higashihara, M
Ogata, T
Tsuji, K
Nakamura, Y
McRae, A
Ogita, K
Yoneda, Y
机构：
[1] GOTHENBURG UNIV,DEPT ANAT & CELL BIOL,S-41390 GOTHENBURG,SWEDEN
[2] SETSUNAN UNIV,DEPT PHARMACOL,HIRAKATA,OSAKA 57301,JAPAN
来源：
MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1996年 / 28卷 / 1-3期
关键词：
ischemia; excitotoxicity; neuronal damage; hypothermia; neuronal protection; glutamate; NMDA receptor; AP-1;
D O I：
10.1007/BF02815222
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The significance of mild hypothermia as a therapeutic measure for ischemic brain damage is presented on the basis of different experimental results. An extracellular glutamate surge, a sustained activation of N-methyl-D-aspartate (NMDA) receptors, and an enhancement of DNA binding activity to transcription factor AP-1, all being key items directly linked to excitotoxic neuronal damage, are deeply affected by slightly lowering temperature (mild hypothermia [MH]). The cellular mechanism of MH seems rather nonspecific but tends to collectively involve these key items rendering neurons resistant to ischemic damage. Clinical application of MH should be a great challenge to relieve deadly effects on central neurons.
引用
收藏
页码：191 / 195
页数：5
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