Steroid profiling in preeclamptic women: evidence for aromatase deficiency

被引：90

作者：

Hertig, Alexandre ^{[1
,2
,5
]}

Liere, Philippe ^{[6
]}

Chabbert-Buffet, Nathalie ^{[4
,5
]}

Fort, Julie ^{[8
]}

Pianos, Antoine ^{[6
]}

Eychenne, Bernard ^{[6
]}

Cambourg, Annie ^{[6
]}

Schumacher, Michael ^{[6
]}

Berkane, Nadia ^{[4
]}

Lefevre, Guillaume ^{[3
]}

Uzan, Serge ^{[4
,5
]}

Rondeau, Eric ^{[1
,2
,5
]}

Rozenberg, Patrick ^{[8
]}

Rafestin-Oblin, Marie-Edith ^{[7
]}

机构：

[1] Hop Tenon, APHP, F-75970 Paris, France

[2] Hop Tenon, INSERM, U702, F-75970 Paris, France

[3] Hop Tenon, Serv Biochim & Hormonol, F-75970 Paris, France

[4] Hop Tenon, Serv Obstet & Gynecol, F-75970 Paris, France

[5] Univ Paris 06, Paris, France

[6] Univ Paris 11, INSERM, UMR788, Paris, France

[7] Ctr Rech Biomed Bichat Beaujon, INSERM, U773, Paris, France

[8] Hop Poissy, Serv Obstet & Gynecol, Poissy, France

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 05期

关键词：

aromatase; estradiol; preeclampsia; 2-methoxyoestradiol; HUMAN PLACENTAL MICROSOMES; HYPERTENSIVE PREGNANCIES; LIPID-PEROXIDATION; PRIMATE PREGNANCY; PRE-ECLAMPSIA; PLASMA; ESTROGEN; EXPRESSION; CELLS; 2-METHOXYOESTRADIOL;

D O I：

10.1016/j.ajog.2010.06.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Experimental data have revealed the critical role played by 2-methoxy-estradiol, a metabolite of 17 beta-estradiol, in the pathophysiology of preeclampsia. We used gas chromatography/mass spectrometry to measure a whole panel of hormonal steroids in the plasma from women during the third trimester of their pregnancy. STUDY DESIGN: The population study consists of 24 pregnant patients with different outcomes: normal, or complicated by isolated preeclampsia or by severe preeclampsia with Hemolysis Enzyme Liver Low Platelets (HELLP) syndrome. RESULTS: 17 beta-estradiol was reduced by 50% in isolated preeclampsia, and by 70% in severe preeclampsia with HELLP syndrome (normal: 8.54 +/- 0.9 ng/mL; isolated preeclampsia: 4.65 +/- 1.0 ng/mL; severe preeclampsia with HELLP syndrome: 2.64 +/- 0.4 ng/mL), as is estrone. Downstream, 2-methoxy-estradiol was decreased only in severe preeclampsia with HELLP syndrome. The concentrations of estrone and 17 beta-estradiol precursors were comparable between groups, suggesting that placental aromatase is deficient in preeclampsia. CONCLUSION: The gradual decrease of estrogen levels with increasing severity of preeclampsia suggests an impairment of placental steroidogenesis.

引用

页码：477.e1 / 477.e9

页数：9

共 43 条

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