Mammographic density as a risk factor for breast cancer in a German case-control study

被引:53
作者
Heusinger, Katharina [2 ]
Loehberg, Christian R. [2 ]
Haeberle, Lothar [2 ]
Jud, Sebastian M. [2 ]
Klingsiek, Peter [2 ]
Hein, Alexander [2 ]
Bayer, Christian M. [2 ]
Rauh, Claudia [2 ]
Uder, Michael [3 ]
Cavallaro, Alexander [3 ]
May, Matthias S. [3 ]
Adamietz, Boris [3 ]
Schulz-Wendtland, Ruediger [3 ]
Wittenberg, Thomas [4 ]
Wagner, Florian [4 ]
Beckmann, Matthias W. [2 ]
Fasching, Peter A. [1 ]
机构
[1] Univ Calif Los Angeles, Dept Med, Div Hematol & Oncol, David Geffen Sch Med, Santa Monica, CA 90404 USA
[2] Erlangen Univ Hosp, Univ Breast Ctr Franconia, Erlangen, Germany
[3] Erlangen Univ Hosp, Inst Diagnost Radiol, Erlangen, Germany
[4] Fraunhofer Inst Integrated Circuits IIS, Erlangen, Germany
关键词
breast cancer risk; case-control study; mammographic percent density; PARENCHYMAL PATTERNS; QUANTITATIVE ASSESSMENT; FAMILY-HISTORY; UNITED-STATES; ASSOCIATION; WOMEN; MODEL; POLYMORPHISM; DISEASE; GENE;
D O I
10.1097/CEJ.0b013e328341e2ce
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Mammographic percent density (MD) is recognized as one of the strongest risk factors associated with breast cancer. This matched case-control study investigated whether MD represents an independent risk factor. Mammograms were obtained from 1025 breast cancer patients and from 520 healthy controls. MD was measured using a quantitative computer-based threshold method (0-100%). Breast cancer patients had a higher MD than healthy controls (38 vs. 32%, P < 0.01). MD was significantly higher in association with factors such as age over 60 years, body mass index (BMI) of 25-30 kg/m(2), nulliparity or low parity (one to two births). Average MD was inversely associated with age, BMI, parity and positively associated with age at first full-term pregnancy. MD was higher in women with at least one first-degree relative affected, but only among patients and not in the group of healthy controls (P < 0.01/P = 0.61). In women with an MD of 25% or more, the risk of breast cancer was doubled compared with women with an MD of less than 10% (odds ratio: 2.1; 95% confidence interval: 1.3-3.4; P < 0.01); in the postmenopausal subgroup, the risk was nearly tripled (odds ratio: 2.7; 95% confidence interval: 1.6-4.7; P < 0.001). This study provides further evidence that MD is an important risk factor for breast cancer. These results indicate strong associations between MD and the risk of breast cancer in a matched case-control study in Germany. European Journal of Cancer Prevention 20:1-8 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:1 / 8
页数:8
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