Copper-Catalyzed Cascade Reactions of Substituted 4-Iodopyrazolecarbaldehydes with 1,2-Phenylenediamines and 2-Aminophenols

被引：26

作者：

Nayak, Maloy ^{[1
]}

Batra, Sanjay ^{[1
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 18期

关键词：

C-N coupling; C-O coupling; copper; diazepines; oxazepines; pyrazoles; PYRAZOLES; POTENT; INHIBITORS; DISCOVERY; SERIES;

D O I：

10.1002/adsc.201000662

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new approach for the synthesis of novel annulated-pyrazoles is presented. This protocol includes an intermolecular condensation followed by a copper-mediated intramolecular C-N or C-O coupling reaction. The method is applied to a range of substituted 4-iodopyrazolecarbaldehydes which react with 1,2-phenylenediamines or 2-aminophenols to yield substituted 2,4- or 1,4-dihydrobenzo[b]pyrazolo[4,3-e][1,4]diazepines or substituted-2H- or 1H-benzo[b]pyrazolo[3,4-f][1,4]-oxazepines, respectively.

引用

页码：3431 / 3437

页数：7

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