The Potential of Probiotics to Prevent Clostridium difficile Infection

被引：19

作者：

Allen, Stephen J. ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 01期

关键词：

C difficile diarrhea; Probiotic; Lactobacilli; Bifidobacteria; Saccharomyces boulardii; ANTIBIOTIC-ASSOCIATED DIARRHEA; DOUBLE-BLIND; INTESTINAL MICROBIOTA; BIFIDOBACTERIA; LACTOBACILLI; MULTICENTER; MULTISTRAIN; INHIBITION; EFFICACY; THERAPY;

D O I：

10.1016/j.idc.2014.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exposure to antibiotics is the major risk factor for Clostridium difficile diarrhea (CDD), suggesting that impairment of colonization resistance due to depletion of the gut flora is a significant underlying disease susceptibility factor. Many properties of probiotic organisms indicate that they may be able to replenish the depleted gut flora and restore colonization resistance. However, despite numerous clinical trials, the evidence base for probiotics in the prevention of CDD remains weak. A recent large trial of a multistrain, high-dose probiotic did not show clear evidence of efficacy. The role of probiotics in the prevention of CDD remains unclear.

引用

页码：135 / +

页数：11

共 42 条

[1]

Allen SJ, 2013, HEALTH TECHNOL ASSES, V17, P1, DOI 10.3310/hta17570

[2] Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial [J].

Allen, Stephen J. ;

Wareham, Kathie ;

Wang, Duolao ;

Bradley, Caroline ;

Hutchings, Hayley ;

Harris, Wyn ;

Dhar, Anjan ;

Brown, Helga ;

Foden, Alwyn ;

Gravenor, Michael B. ;

Mack, Dietrich .

LANCET, 2013, 382 (9900) :1249-1257

[3] Effect of Antibiotic Treatment on the Intestinal Metabolome [J].

Antunes, L. Caetano M. ;

Han, Jun ;

Ferreira, Rosana B. R. ;

Lolic, Petra ;

Borchers, Christoph H. ;

Finlay, B. Brett .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (04) :1494-1503

[4] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[5] Clostridium difficile infection in Europe: a hospital-based survey [J].

Bauer, Martijn P. ;

Notermans, Daan W. ;

van Benthem, Birgit H. B. ;

Brazier, Jon S. ;

Wilcox, Mark H. ;

Rupnik, Maja ;

Monnet, Dominique L. ;

van Dissel, Jaap T. ;

Kuijper, Ed J. .

LANCET, 2011, 377 (9759) :63-73

[6] Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells [J].

Boonma, Prapaporn ;

Spinler, Jennifer K. ;

Venable, Susan F. ;

Versalovic, James ;

Tumwasorn, Somying .

BMC MICROBIOLOGY, 2014, 14

[7] Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile [J].

Britton, Robert A. ;

Young, Vincent B. .

GASTROENTEROLOGY, 2014, 146 (06) :1547-1553

[8] Health benefits of probiotics: are mixtures more effective than single strains? [J].

Chapman, C. M. C. ;

Gibson, G. R. ;

Rowland, I. .

EUROPEAN JOURNAL OF NUTRITION, 2011, 50 (01) :1-17

[9] Composition, variability, and temporal stability of the intestinal microbiota of the elderly [J].

Claesson, Marcus J. ;

Cusack, Siobhan ;

O'Sullivan, Orla ;

Greene-Diniz, Rachel ;

de Weerd, Heleen ;

Flannery, Edel ;

Marchesi, Julian R. ;

Falush, Daniel ;

Dinan, Timothy ;

Fitzgerald, Gerald ;

Stanton, Catherine ;

van Sinderen, Douwe ;

O'Connor, Michael ;

Harnedy, Norma ;

O'Connor, Kieran ;

Henry, Colm ;

O'Mahony, Denis ;

Fitzgerald, Anthony P. ;

Shanahan, Fergus ;

Twomey, Cillian ;

Hill, Colin ;

Ross, R. Paul ;

O'Toole, Paul W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4586-4591

[10] Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea:: a systematic review [J].

Dendukuri, N ;

Costa, V ;

McGregor, M ;

Brophy, JM .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2005, 173 (02) :167-170

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