Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase

被引：122

作者：

Mitsukura, Koichi ^{[1
]}

Suzuki, Mai ^{[1
]}

Tada, Kazuhiro ^{[1
]}

Yoshida, Toyokazu ^{[1
]}

Nagasawa, Toru ^{[1
]}

机构：

[1] Gifu Univ, Dept Biomol Sci, Gifu 5011193, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 20期

关键词：

CANDIDA-PARAPSILOSIS ATCC-7330; ACETOBACTERIUM-WOODII; BIOCATALYTIC ROUTES; ALCOHOLS; ACIDS;

D O I：

10.1039/c0ob00353k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Streptomyces sp. GF3587 and 3546 were found to be iminereducing strains with high R- and S-selectivity by screening using 2-methyl-1-pyrroline (2-MPN). Their whole-cell catalysts produced 91 mM R-2-methylpyrrolidine (R-2-MP) with 99.2% e.e. and 27.5 mM S-2-MP (92.3% e.e.) from 2-MPN at 91-92% conversion in the presence of glucose, respectively.

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收藏

页码：4533 / 4535

页数：3

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