Original LncRNA MEG3 regulates breast cancer proliferation and apoptosis through miR-141-3p/RBMS3 axis

被引：41

作者：

Dong, Shiliang ^{[1
]}

Ma, Minrui ^{[2
]}

Li, Ming ^{[3
]}

Guo, Yuexin ^{[1
]}

Zuo, Xiaoxiao ^{[1
]}

Gu, Xiaobin ^{[1
]}

Zhang, Mingzhi ^{[2
]}

Shi, Yonggang ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Radiat Oncol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou 450052, Henan, Peoples R China

[3] Peoples Hosp Laibin, Dept Oncol, Laibin City 546100, Guangxi Provinc, Peoples R China

来源：

GENOMICS | 2021年 / 113卷 / 04期

关键词：

Breast cancer; Maternally expressed 3; miR-141-3p; RNA binding motif single stranded; interacting protein 3 axis; Apoptosis; Cell proliferation; RNA-BINDING PROTEIN; POOR-PROGNOSIS; CHROMOSOME; 3P; HEALTH-CARE; RBMS3; EXPRESSION; COUNTRIES; GENES; METASTASIS; CELLS;

D O I：

10.1016/j.ygeno.2021.04.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Maternally expressed 3 (MEG3) and RNA binding motif single stranded interacting protein 3 (RBMS3) are abnormally expressed in breast cancer susceptibility genes (BRCA), but the mechanism of the two in breast cancer (BC) is unclear. By performing in vivo and in vitro experiments, we found that MEG3 and RBMS3 were low-expressed, negatively correlated with high-expressed miR-141-3p, were positively correlated with each other in BC. MEG3 targeted miR-141-3p, and miR-141-3p targeted RBMS3. MEG3, which was mainly distributed in BC cytoplasm, could down-regulate miR-141-3p and up-regulate RBMS3, and reverse effect of miR-141-3p on related gene expressions and on promoting cancer development. Overexpressed MEG3 inhibited growth of xenografts, promoted cell apoptosis via regulating apoptosis related factors, and up-regulated RBMS3 expression but down-regulated miR-141-3p. The findings of this study showed that MEG3 inhibited proliferation and promoted apoptosis of BC cells through the miR-141-3p/RBMS3 axis, and MEG3 inhibited growth of xenografts through miR-141-3p.

引用

页码：1689 / 1704

页数：16

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