Zingerone Alleviates Myocardial Ischemia/Reperfusion Injury

被引：1
作者：
Luo, Fanglin [1 ]
Luo, Shunxiang [1 ]
Wu, Yanqing [1 ]
机构：
[1] Fujian Med Univ, Hosp Nanping City 1, Dept Cardiol, 317 Zhongshan Rd, Nanping 353000, Fujian, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2021年 / 19卷 / 04期
关键词：
Ischemia/reperfusion; Myocardial infarction; NF-kappa B; Nrf2/HO-1; Zingerone; OXIDATIVE STRESS; ANTIOXIDANT; INFLAMMATION; THERAPIES; RATS;
D O I：
10.37290/ctnr2641-452X.19:543-549
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Using a rat model, we have explored the underlying mechanism of ischemia/reperfusion (I/R)-mediated myocardial infarction and assessed the protective potential of zingerone. The results show that zingerone exhibits not only the myocardial protective effect, but also antioxidative and anti-inflammatory effects by suppression of markers of oxidation and proinflammatory cytokine release. Zingerone promotes protective effects against I/R-induced myocardial infarction by regulating Nrf2/HO-1 and NF-kappa B signaling pathways. These findings provide novel insights into the effects of zingerone on the cardioprotective mechanism of myocardial injury after I/R and may open new avenues for myocardial infarction treatment.
引用
收藏
页码：543 / 549
页数：7
相关论文
共 29 条
[11]   Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney [J].
Kandemir, Fatih Mehmet ;
Yildirim, Serkan ;
Kucukler, Sefa ;
Caglayan, Cuneyt ;
Mahamadu, Amdia ;
Dortbudak, Muhammet Bahaeddin .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 105 :981-991
[12]   Reactive oxygen species as mediators of cardiac injury and protection: The relevance to anesthesia practice [J].
Kevin, LG ;
Novalija, E ;
Stowe, DF .
ANESTHESIA AND ANALGESIA, 2005, 101 (05) :1275-1287
[13]   The Mechanism of Action of Zingerone in the Pacemaker Potentials of Interstitial Cells of Cajal Isolated from Murine Small Intestine [J].
Kim, Jung Nam ;
Kim, Hyun Jung ;
Kim, Iksung ;
Kim, Yun Tai ;
Kim, Byung Joo .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 46 (05) :2127-2137
[14]   Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway [J].
Kim, Mi Kyung ;
Chung, Sang Woon ;
Kim, Dae Hyun ;
Kim, Ji Min ;
Lee, Eun Kyeong ;
Kim, Ji Young ;
Ha, Young Mi ;
Kim, Yun Hee ;
No, Jae-Kyung ;
Chung, Hye Sun ;
Park, Kun-Young ;
Rhee, Sook Hee ;
Choi, Jae Sue ;
Yu, Byung Pal ;
Yokozawa, Takako ;
Kim, Young Jin ;
Chung, Hae Young .
EXPERIMENTAL GERONTOLOGY, 2010, 45 (06) :419-426
[15]   Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure [J].
Kingery, Justin R. ;
Hamid, Tariq ;
Lewis, Robert K. ;
Ismahil, Mohamed Ameen ;
Bansal, Shyam S. ;
Rokosh, Gregg ;
Townes, Tim M. ;
Ildstad, Suzanne T. ;
Jones, Steven P. ;
Prabhu, Sumanth D. .
BASIC RESEARCH IN CARDIOLOGY, 2017, 112 (02)
[16]   Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury [J].
Li, Haobo ;
Xia, Zhengyuan ;
Chen, Yanfang ;
Qi, Dake ;
Zheng, Hong .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[17]   Nuclear factor-κB inhibition improves myocardial contractility in rats with cirrhotic cardiomyopathy [J].
Liu, Hongqun ;
Lee, Samuel S. .
LIVER INTERNATIONAL, 2008, 28 (05) :640-648
[18]   Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway [J].
Meng, Xiangli ;
Hu, Lin ;
Li, Wenqiang .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2019, 392 (11) :1421-1433
[19]   The protective role of curcumin in myocardial ischemia-reperfusion injury [J].
Mokhtari-Zaer, Amin ;
Marefati, Narges ;
Atkin, Stephen L. ;
Butler, Alexandra E. ;
Sahebkar, Amirhossein .
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (01) :214-222
[20]   Consumption of a defined, plant-based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks [J].
Najjar, Rami S. ;
Moore, Carolyn E. ;
Montgomery, Baxter D. .
CLINICAL CARDIOLOGY, 2018, 41 (08) :1062-1068
123