Zingerone Alleviates Myocardial Ischemia/Reperfusion Injury

被引：1
作者：
Luo, Fanglin [1 ]
Luo, Shunxiang [1 ]
Wu, Yanqing [1 ]
机构：
[1] Fujian Med Univ, Hosp Nanping City 1, Dept Cardiol, 317 Zhongshan Rd, Nanping 353000, Fujian, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2021年 / 19卷 / 04期
关键词：
Ischemia/reperfusion; Myocardial infarction; NF-kappa B; Nrf2/HO-1; Zingerone; OXIDATIVE STRESS; ANTIOXIDANT; INFLAMMATION; THERAPIES; RATS;
D O I：
10.37290/ctnr2641-452X.19:543-549
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Using a rat model, we have explored the underlying mechanism of ischemia/reperfusion (I/R)-mediated myocardial infarction and assessed the protective potential of zingerone. The results show that zingerone exhibits not only the myocardial protective effect, but also antioxidative and anti-inflammatory effects by suppression of markers of oxidation and proinflammatory cytokine release. Zingerone promotes protective effects against I/R-induced myocardial infarction by regulating Nrf2/HO-1 and NF-kappa B signaling pathways. These findings provide novel insights into the effects of zingerone on the cardioprotective mechanism of myocardial injury after I/R and may open new avenues for myocardial infarction treatment.
引用
收藏
页码：543 / 549
页数：7
相关论文
共 29 条
[1]   Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity [J].
Alibakhshi, Tuba ;
Khodayar, Mohammad Javad ;
Khorsandi, Layasadat ;
Rashno, Mohammad ;
Zeidooni, Leila .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 105 :225-232
[2]   The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection [J].
Andreadou, Ioanna ;
Schulz, Rainer ;
Papapetropoulos, Andreas ;
Turan, Belma ;
Ytrehus, Kirsti ;
Ferdinandy, Peter ;
Daiber, Andreas ;
Di Lisa, Fabio .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (12) :6510-6522
[3]  
Arulkumar R., 2019, SDRP J FOOD SCI TECH, V4, DOI [10.25177/JFST.4.5, DOI 10.25177/JFST.4.5]
[4]  
Azam F., 2017, NEUROPROTECTIVE EFFE, P49
[5]   Intermittent Hypoxia Prevents Myocardial Mitochondrial Ca2+ Overload and Cell Death during Ischemia/Reperfusion: The Role of Reactive Oxygen Species [J].
Chang, Jui-Chih ;
Lien, Chih-Feng ;
Lee, Wen-Sen ;
Chang, Huai-Ren ;
Hsu, Yu-Cheng ;
Luo, Yu-Po ;
Jeng, Jing-Ren ;
Hsieh, Jen-Che ;
Yang, Kun-Ta .
CELLS, 2019, 8 (06)
[6]   Progress in Therapies for Myocardial Ischemia Reperfusion Injury [J].
Chi, Hong-jie ;
Chen, Mu-lei ;
Yang, Xin-chun ;
Lin, Xiang-min ;
Sun, Hao ;
Zhao, Wen-shu ;
Qi, Dan ;
Dong, Jia-lu ;
Cai, Jun .
CURRENT DRUG TARGETS, 2017, 18 (15) :1712-1721
[7]  
Farhangi MA, 2016, ARCH IRAN MED, V19, P470, DOI 0161907/AIM.005
[8]   Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges [J].
Huang, Shuaibo ;
Frangogiannis, Nikolaos G. .
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 175 (09) :1377-1400
[9]   Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models [J].
Javed, Hayate ;
Meeran, Mohamed Fizur Nagoor ;
Azimullah, Sheikh ;
Adem, Abdu ;
Sadek, Bassem ;
Ojha, Shreesh Kumar .
FRONTIERS IN PHARMACOLOGY, 2019, 9
[10]  
Jesudoss VAS, 2017, GASTROINTESTINAL TISSUE: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, P289, DOI 10.1016/B978-0-12-805377-5.00021-7
123