Salivary Gland Branching Morphogenesis - Recent Progress and Future Opportunities

被引:40
作者
Hsu, Jeff Chi-Feng [1 ]
Yamada, Kenneth M. [1 ]
机构
[1] Natl Inst Dent & Craniofacial Res, NIH, Lab Cell & Dev Biol, Bethesda, MD 20892 USA
关键词
salivary gland; epithelium; branching morphogenesis; fibronectin; E-cadherin; growth factor; EMBRYONIC SUBMANDIBULAR-GLAND; GROWTH-FACTOR RECEPTOR; EPITHELIAL MORPHOGENESIS; E-CADHERIN; GENE-EXPRESSION; CELL; EGF; MICE; LOCALIZATION; INVOLVEMENT;
D O I
10.4248/IJOS10042
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.
引用
收藏
页码:117 / 126
页数:10
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