Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside

被引：17

作者：

Pawlowski, Matthias ^{[1
]}

Meuth, Sven G. ^{[1
]}

Duning, Thomas ^{[1
]}

机构：

[1] Univ Hosp Munster, Dept Neurol, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany

来源：

DIAGNOSTICS | 2017年 / 7卷 / 03期

关键词：

Alzheimer's disease; dementia; fluid biomarkers; cerebrospinal fluid; amyloid-beta; tau; AMYLOID PRECURSOR PROTEIN; MICROTUBULE-ASSOCIATED PROTEIN; PAIRED HELICAL FILAMENTS; MILD COGNITIVE IMPAIRMENT; PHOSPHORYLATED TAU-PROTEIN; BETA-PROTEIN; NEUROFIBRILLARY TANGLES; NATIONAL INSTITUTE; ABNORMAL PHOSPHORYLATION; ASSOCIATION WORKGROUPS;

D O I：

10.3390/diagnostics7030042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer's disease. In parallel, assays for the detection of biomarkers that reflect the typical Alzheimer's disease-associated pathology have been developed and validated in myriads of clinical studies. Such biomarkers complement clinical diagnosis and improve diagnostic accuracy. The use of biomarkers will become even more important with the advent of disease-modifying therapies. Such therapies will likely be most beneficial when administered early in the disease course. Here, we summarise the development of the core Alzheimer's disease cerebrospinal fluid biomarkers: amyloid- and tau. We provide an overview of their role in cellular physiology and Alzheimer's disease pathology, and embed their development as cerebrospinal fluid biomarkers into the historical context of Alzheimer's disease research. Finally, we summarise recommendations for their use in clinical practice, and outline perspectives for novel cerebrospinal fluid candidate biomarkers.

引用

页数：21

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