Synthesis, Crystal Structure and DNA Interaction of Substituted Aromatic Crown Ether and Its Complexes

:3,3' -dimethyl-dibenzo-18-crown-6 (MDB18-C-6) and the complexes of crown ether with nickel (l), palladium(l) and K2(i-mnt) has been synthesized, respectively. Complex [K(MDB18-C-6)(CH3COCH3)](2)[Ni(i-mnt)(2)] (1) and [K(MDB18-C-6)(CH3SOCH3)](2)[Pd(i-mnt)(2)] (2) were characterized by elemental analysis, IR, UV, H-1 NMR spectra and MS. The crystal structures of these two complexes have been determined by single crystal X-ray diffraction analysis. The DNA-binding properties of complexes 1 and 2 with calf thymus DNA (CT-DNA) have also been investigated by UV absorption, fluorescence and circular dichroism (CD) spectra. The results show that the two complexes have interaction with DNA. The helical structure of DNA is mainly affected by the complexes, causing a conformational change in the DNA, and the interaction intensity of complex 2 is better than complex 1. CCDC: 922022, 1; 1000767, 2.