Metronomic Maintenance Therapy for Rhabdomyosarcoma

被引：6

作者：

Andre, Nicolas ^{[1
,2
,3
]}

Corradini, Nadege ^{[4
]}

Shaked, Yuval ^{[3
,5
]}

机构：

[1] Hop Enfants La Timone, AP HM, Pediat Hematol & Oncol Dept, Marseille, France

[2] Univ Aix Marseille, Ctr Rech Cancerol Marseille, SMARTc Unit, INSERM,U1068, Marseille, France

[3] Metron Global Hlth Initiat, Marseille, France

[4] Inst Hematol & Oncol Pediat, Lyon, France

[5] Technion Israel Inst Technol, Fac Med Cell Biol & Canc Sci, Technion Integrated Canc Ctr, Haifa, Israel

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 12期

关键词：

HIGH-DOSE CHEMOTHERAPY; CHILDREN; EFFICACY;

D O I：

10.1016/j.trecan.2019.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a recent article, Bisogno et al. reported in a randomized trial that addition of metronomic maintenance therapy (MMT) with vinorelbine plus cyclophosphamide for children with rhabdomyosarcoma resulted in a significant increase in overall and event-free survival. Although the mechanism of action remains to be fully elucidated, this study paves the way for further evaluation of MMT as a potential therapeutic strategy in pediatric patients with high-risk disease.

引用

页码：756 / 759

页数：5

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