Expression of intercellular adhesion molecule-1 (ICAM-1) during ischemia-reperfusion in human liver tissue allograft: Image analysis by confocal laser scanning microscopy

被引：10
作者：
Benkoel, L
Dodero, F
Hardwigsen, J
Benoliel, AM
Bongrand, P
Botta-Fridlund, D
Le Treut, YP
Chamlian, A
Lombardo, D
机构：
[1] Fac Med Marseille, INSERM, U559, F-13385 Marseille 05, France
[2] Hop Conception, Serv Chirurg Gen & Transplantat Hepat, F-13385 Marseille, France
[3] Hop Conception, Serv Hepatogastroenterol, F-13385 Marseille 05, France
[4] Hop St Marguerite, INSERM, U387, F-13009 Marseille, France
来源：
DIGESTIVE DISEASES AND SCIENCES | 2003年 / 48卷 / 11期
关键词：
human liver allografts; ischemia-reperfusion; ICAM-1; confocal laser scanning microscopy;
D O I：
10.1023/B:DDAS.0000004521.88660.fd
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We studied and quantified the effect of ischemia-reperfusion on expression of intercellular adhesion molecule-1 (ICAM-1) on sinusoidal endothelial cells and hepatocyte plasma membranes by means of confocal laser scanning microscopy imaging. We found that ischemia induced an increase in ICAM-1 expression on sinusoidal endothelial cells and hepatocytes. After reperfusion, ICAM-1 expression was increased on sinusoidal endothelial cells, whereas it was unmodified on hepatocytes. On the other hand, ICAM-1 expression was not correlated to ischemia-reperfusion liver injury. Therefore, hepatocellular ischemia-reperfusion injury could be induced by other causes than immune-mediated damages.
引用
收藏
页码：2167 / 2172
页数：6
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