Inhibitory effect of simvastatin on the TNF-α- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation

被引：24

作者：

Park, Su-Young ^{[1
]}

Lee, Jong-Suk ^{[1
]}

Ko, Yu Jin ^{[1
]}

Kim, Ah Ra ^{[1
]}

Choi, Mi Kyoung ^{[1
]}

Kwak, Mi-Kyoung ^{[1
]}

Choi, Han Gon ^{[1
]}

Yong, Chul Soon ^{[1
]}

Kim, Jung-Ae ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 02期

关键词：

reactive oxygen species; tumor necrosis factor-alpha; angiotensin II; mevalonate; simvastatin; monocyte-endothelial cell adhesion;

D O I：

10.1007/s12272-001-1141-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vascular endothelial cell activation by cytokines and other pro-inflammatory mediators is an initial event in atherosclerosis and in other vascular diseases. Simvastatin, a HMG-CoA reductase inhibitor, suppressed both tumor necrosis factor (TNF)-alpha- and angiotensin (Ang) II-induced monocyte adhesion to endothelial cells (an initial step in vascular inflammation) and reactive oxygen species (ROS) production. Diphenyleneiodonium and apocynin, both NADPH oxidase inhibitors, also suppressed TNF-alpha-induced ROS and monocyte-endothelial cell adhesion, demonstrating that TNF-alpha-induced monocyte adhesion is mediated through ROS produced by NADPH oxidase activation. Furthermore, exogenously applied mevalonate or geranylgeranylpyrophosphate in combination with simvastatin completely prevented the inhibitory effects of simvastatin on ROS generation and monocyte-endothelial cell adhesion by TNF-alpha and Ang II. These results suggest that monocyte adhesion to endothelial cells induced by TNF-alpha or Ang II is mediated via the geranylgeranyl isoprenoid-dependent generation of ROS, and that this is inhibited by simvastatin.

引用

页码：195 / 204

页数：10