Vitamin D deficiency in pregnant women with pih and neonates and their correlation

Objective: To explore the correlation between the 25-hydroxy vitamin D (vitamin D) levels in pregnant women with pregnancy-induced hypertension (PIH) and the level in neonates, and investigate the effects of vitamin D levels in pregnant women with PIH on neonates with vitamin D deficiency. Methods: A retrospective analysis was performed on 249 pregnant women with preeclampsia and their neonates. Vitamin D concentrations in the serum of pregnant women and neonates were measured using LC-MS/MS. Vitamin D levels in neonates born to pregnant women with PIH at different vitamin D levels were compared, and the correlation of vitamin D levels between pregnant women and their neonates were analyzed. Results: The expression level of pregnant women in the vitamin D sufficient group was 38.24 +/- 7.62 ng/mL, which was significantly higher than that of PIH pregnant women with inadequate and deficient vitamin D levels (P<0.05). The expression level of neonates in the vitamin D sufficient group was 24.57 +/- 4.26 ng/mL, which was significantly higher than that of neonates with inadequate and deficient vitamin D levels (P<0.05). Vitamin D levels in pregnant women and neonates were positively correlated (r=7.45, P<0.05). The critical value of vitamin D (<= 27.55 ng/mL) for pregnant women with PIH was used to predict the sensitivity of neonatal vitamin D expression levels at 94.82%, with a specificity of 76.95%. Conclusion: Vitamin D level of pregnant women with PIH is positively correlated with that of the neonates, and whether neonates have vitamin D deficiency can be effectively determined based on the vitamin D level of pregnant women with PIH.