Saikosaponins from Bupleurum chinense and inhibition of HBV DNA replication activity

被引：1
|
作者：
Yin, Feng [1 ,2 ]
Pan, Ruixiang [1 ]
Chen, Rongmin [1 ]
Hu, Lihong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
[2] Ric Biosci LLC, Dept Drug Discovery, Concord, OH 44077 USA
来源：
NATURAL PRODUCT COMMUNICATIONS | 2008年 / 3卷 / 02期
关键词：
Bupleurum chinense; saikosaponins; inhibition of HBV DNA replication;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new saikosaponin, 3 beta,16 alpha,23,28,30-pentahydroxyoleana 11,13(18)-diene 3-O-beta-D-fucopyranoside (1), along with eight known compounds, saikosaponin a, b(1), b(2), b(3), d, g, k, and 1 were isolated from the MeOH extract of the aerial parts of Bupleurum chinense DC. Their structures were elucidated by 1D and 2D NMR spectral interpretation, as well as by chemical degradation. Saikosaponin d exhibited significant bioactivity in inhibiting HBV DNA replication.
引用
收藏
页码：155 / 157
页数：3
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