Increased Expression of PCNA-AS1 in Colorectal Cancer and its Clinical Association

被引：9

作者：

Cai, Fengbo ^{[1
,2
]}

Li, Juntang ^{[2
]}

Pan, Xuefeng ^{[2
]}

Zhang, Changshan ^{[2
]}

Wei, Dong ^{[2
]}

Gao, Chunfang ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Dept Gen Surg, Clin Med Coll 150, 800 Xiangyin Rd, Shanghai 200433, Peoples R China

[2] 150th Cent Hosp PLA, Dept Gen Surg, Inst Anal Colorectal Surg, Luoyang, Peoples R China

来源：

CLINICAL LABORATORY | 2017年 / 63卷 / 11-12期

关键词：

long noncoding RNA; PCNA-AS1; colorectal cancer; tumor marker; CELL NUCLEAR ANTIGEN; LONG NONCODING RNA; DISRUPTION; PROGNOSIS;

D O I：

10.7754/Clin.Lab.2017.170503

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The aim is to study the expression of PCNA-AS1 in colorectal cancer (CRC) tissue and paired-adjacent normal tissue and the relationship between its expression level and clinical pathological features. Methods: Using real-time qPCR, PCNA-AS1 expression levels were detected in 114 cases to establish the relationship between its expression and clinicopathologic features. Moreover, the expressions of PCNA-AS1 were investigated in CRC and normal colonic epithelial cell lines. Results: PCNA-AS1 was upregulated in CRC patients. The difference was statistically significant (p < 0.001). The expression level was significantly correlated with the tumor invasion and TNM stage. The area under the receiver operating characteristic curve, sensitivity, and specificity were 0.824, 0.632, and 0.860, respectively. Moreover, PCNA-AS1 was up-regulated in CRC cell lines. Conclusions: PCNA-AS1 may function as a potential tumor biomarker for diagnosing CRC.

引用

页码：1809 / 1814

页数：6

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