4-HYDROXY-2-QUINOLONES. 194. 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID ALKYLAMIDES. SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES

被引：4

作者：

Ukrainets, I. V. ^{[1
]}

Golik, N. Yu. ^{[1
]}

Andreeva, K. V. ^{[1
]}

Gorokhova, O. V. ^{[1
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 46卷 / 12期

关键词：

4-hydroxy-2-oxoquinoline-3-carboxylic acid alkylamides; amidation; diuretic activity; X-ray structural analysis;

D O I：

10.1007/s10593-011-0692-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modified methods are proposed for the preparation of the ethyl ester and alkylamides of 1-hydroxy-3- oxo-6,7-dihydro-3H, 5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. A comparative analysis has been carried out of the steric structure and diuretic activity of the synthesized compounds and the previously studied, and closely structurally related, 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo-[3,2,1-ij]quinoline-2-carboxamides.

引用

页码：1459 / 1466

页数：8

共 14 条

[1]

[Anonymous], 2007, Chem. Heterocycl. Compd, DOI DOI 10.1007/S10593-007-0220-9

[2]

Burgi H.-B., 1994, Structure Correlation, P741, DOI [10.1002/9783527616091, DOI 10.1002/9783527616091]

[3] Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity .1. Reaction of methanetricarboxylates with indoline and 1,2,3,4-tetrahydroquinoline [J].