Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside

被引：38
|
作者：
Ye, Le-Chi [1 ]
Zhu, De-Xiang [2 ]
Qiu, Jun-Jun [3 ]
Xu, Jianmin [2 ]
Wei, Ye [2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Wenzhou, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China
[3] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai 200032, Peoples R China
来源：
ONCOLOGY LETTERS | 2015年 / 9卷 / 03期
基金：
中国国家自然科学基金;
关键词：
long non-coding RNA; colorectal cancer; TRANSCRIBED-ULTRACONSERVED REGIONS; POOR-PROGNOSIS; GENE; PSEUDOGENE; EXPRESSION; HOTAIR; GROWTH; MEG3; 8Q24; H19;
D O I：
10.3892/ol.2015.2846
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is one of the greatest threats to public health. Recent advances in whole-genome transcriptome analyses have enabled the identification of numerous members of a novel class of non-coding (nc)RNA, long ncRNA (lncRNA), which is broadly defined as RNA molecules that are >200 nt in length and lacking an open reading frame. In the present review, all lncRNAs associated with CRC are briefly summarized, with a particular focus on their potential roles as clinical biomarkers. CRC-associated lncRNAs involved in the underlying mechanisms of CRC progression are also initially included. This should benefit the development of novel markers and effective therapeutic targets for patients with CRC.
引用
收藏
页码：1039 / 1045
页数：7
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