Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside

被引：39

作者：

Ye, Le-Chi ^{[1
]}

Zhu, De-Xiang ^{[2
]}

Qiu, Jun-Jun ^{[3
]}

Xu, Jianmin ^{[2
]}

Wei, Ye ^{[2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Wenzhou, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China

[3] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai 200032, Peoples R China

来源：

ONCOLOGY LETTERS | 2015年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; colorectal cancer; TRANSCRIBED-ULTRACONSERVED REGIONS; POOR-PROGNOSIS; GENE; PSEUDOGENE; EXPRESSION; HOTAIR; GROWTH; MEG3; 8Q24; H19;

D O I：

10.3892/ol.2015.2846

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is one of the greatest threats to public health. Recent advances in whole-genome transcriptome analyses have enabled the identification of numerous members of a novel class of non-coding (nc)RNA, long ncRNA (lncRNA), which is broadly defined as RNA molecules that are >200 nt in length and lacking an open reading frame. In the present review, all lncRNAs associated with CRC are briefly summarized, with a particular focus on their potential roles as clinical biomarkers. CRC-associated lncRNAs involved in the underlying mechanisms of CRC progression are also initially included. This should benefit the development of novel markers and effective therapeutic targets for patients with CRC.

引用

页码：1039 / 1045

页数：7

共 72 条

[1] Mutational and Expressional Analyses of PTEN Gene in Colorectal Cancer From Northern India [J].

Ali, Asgar ;

Saluja, Sundeep S. ;

Hajela, Krishnan ;

Mishra, Pramod K. ;

Rizvi, Moshahid A. .

MOLECULAR CARCINOGENESIS, 2014, 53 :E45-E52

[2] Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines [J].

Alves, Cleidson Padua ;

Fonseca, Aline Simoneti ;

Muys, Bruna Rodrigues ;

Bueno, Rafaela de Barros e Lima ;

Buerger, Matheus Carvalho ;

de Souza, Jorge E. S. ;

Valente, Valeria ;

Zago, Marco Antonio ;

Silva, Wilson Araujo, Jr. .

STEM CELLS, 2013, 31 (12) :2827-2832

[3]

[Anonymous], BIOMED RES INT

[4]

[Anonymous], WORLD CHINESE J DIGE

[5]

[Anonymous], MOL CARCINOG

[6] p53-dependent Induction of PVT1 and miR-1204 [J].

Barsotti, Anthony M. ;

Beckerman, Rachel ;

Laptenko, Oleg ;

Huppi, Konrad ;

Caplen, Natasha J. ;

Prives, Carol .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (04) :2509-2519

[7] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[8] Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas [J].

Calin, George A. ;

Liu, Chang-Gong ;

Ferracin, Manuela ;

Hyslop, Terry ;

Spizzo, Riccardo ;

Sevignani, Cinzia ;

Fabbri, Muller ;

Cimmino, Amelia ;

Lee, Eun Joo ;

Wojcik, Sylwia E. ;

Shimizu, Masayoshi ;

Tili, Esmerina ;

Rossi, Simona ;

Taccioli, Cristian ;

Pichiorri, Flavia ;

Liu, Xiuping ;

Zupo, Simona ;

Herlea, Vlad ;

Gramantieri, Laura ;

Lanza, Giovanni ;

Alder, Hansjuerg ;

Rassenti, Laura ;

Volinia, Stefano ;

Schmittgen, Thomas D. ;

Kipps, Thomas J. ;

Negrini, Massimo ;

Croce, Carlo M. .

CANCER CELL, 2007, 12 (03) :215-229

[9] Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility [J].

Chung, Suyoun ;

Nakagawa, Hidewaki ;

Uemura, Motohide ;

Piao, Lianhua ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Takata, Ryo ;

Akamatsu, Shusuke ;

Kawaguchi, Takahisa ;

Morizono, Takashi ;

Tsunoda, Tatsuhiko ;

Daigo, Yataro ;

Matsuda, Koichi ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Kubo, Michiaki .

CANCER SCIENCE, 2011, 102 (01) :245-252

[10]

Cui HM, 2002, CANCER RES, V62, P6442

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