Prospects of biological and synthetic pharmacotherapies for glioblastoma

被引：13

作者：

Altshuler, David B. ^{[1
]}

Kadiyala, Padma ^{[1
,2
]}

Nunez, Felipe J. ^{[1
,2
]}

Nunez, Fernando M. ^{[1
,2
]}

Carney, Stephen ^{[1
,2
]}

Alghamri, Mahmoud S. ^{[1
,2
]}

Garcia-Fabiani, Maria B. ^{[1
,2
]}

Asad, Antonela S. ^{[3
]}

Candia, Alejandro J. Nicola ^{[3
]}

Candolfi, Marianela ^{[3
]}

Lahann, Joerg ^{[4
]}

Moon, James J. ^{[4
,5
]}

Schwendeman, Anna ^{[5
,6
]}

Lowenstein, Pedro R. ^{[1
,2
]}

Castro, Maria G. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Deptt Cell & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Buenos Aires, Fac Med, Dept Biol Celular & Histol, Buenos Aires, DF, Argentina

[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[6] Biointerfaces Inst, Zurich, Switzerland

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2020年 / 20卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Glioma; immune checkpoint inhibitors; gene therapy; IDH1; mutation; immunotherapy; BLOOD-BRAIN-BARRIER; GENE-THERAPY; T-CELLS; MONOCLONAL-ANTIBODY; DRUG-DELIVERY; IDH MUTATION; GENOMIC CHARACTERIZATION; ANTIGEN RECEPTORS; MALIGNANT GLIOMAS; CTLA-4; BLOCKADE;

D O I：

10.1080/14712598.2020.1713085

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: The field of neuro-oncology has experienced significant advances in recent years. More is known now about the molecular and genetic characteristics of glioma than ever before. This knowledge leads to the understanding of glioma biology and pathogenesis, guiding the development of targeted therapeutics and clinical trials. The goal of this review is to describe the state of basic, translational, and clinical research as it pertains to biological and synthetic pharmacotherapy for gliomas. Areas covered: Challenges remain in designing accurate preclinical models and identifying patients that are likely to respond to a particular targeted therapy. Preclinical models for therapeutic assessment are critical to identify the most promising treatment approaches. Expert opinion: Despite promising new therapeutics, there have been no significant breakthroughs in glioma treatment and patient outcomes. Thus, there is an urgent need to better understand the mechanisms of treatment resistance and to design effective clinical trials.

引用

页码：305 / 317

页数：13

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