Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4

被引：2
|
作者：
te Molder, Lisa [1 ,4 ]
de Pereda, Jose M. [2 ,3 ]
Sonnenberg, Arnoud [1 ]
机构：
[1] Netherlands Canc Inst, Div Cell Biol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
[2] Univ Salamanca, Ctr Invest Canc, Consejo Super Invest Cient CSIC, Salamanca 37007, Spain
[3] Univ Salamanca, Inst Biol Mol & Celular Canc, Consejo Super Invest Cient CSIC, Salamanca 37007, Spain
[4] Innovencio, Kerkstr 15, NL-5301 EG Zaltbommel, Netherlands
来源：
JOURNAL OF CELL SCIENCE | 2021年 / 134卷 / 18期
关键词：
Cellular tension; Hemidesmosome; Integrin; Keratin; Signaling; Cell adhesion; BETA-4; INTEGRIN; EPIDERMOLYSIS-BULLOSA; CYTOPLASMIC DOMAIN; ALPHA(6)BETA(4) INTEGRIN; DEPENDENT ACTIVATION; TETRASPANIN CD151; PLECTIN REVEALS; ACTIN DYNAMICS; SPLICE VARIANT; MESSENGER-RNA;
D O I：
10.1242/jcs.259004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes to the underlying basement membrane. Integrin alpha 6 beta 4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, alpha 6 beta 4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival. In this Review, we detail the role of alpha 6 beta 4 in HD assembly and beyond, and we discuss the molecular mechanisms that regulate its function.
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页数：13
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