Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

被引：34

作者：

Kang, Eun Seok ^{[1
,2
]}

Lee, Geun Taek ^{[1
]}

Kim, Beom Seok ^{[3
]}

Kim, Chul Hoon ^{[1
,4
]}

Seo, Gi Ho ^{[1
,4
]}

Han, Seung Jin ^{[1
]}

Hur, Kyu Yeon ^{[1
]}

Ahn, Chul Woo ^{[1
,2
]}

Ha, Hunjoo ^{[5
,6
]}

Jung, Mankil ^{[7
]}

Ahn, Youn Soo ^{[1
,4
]}

Cha, Bong Soo ^{[1
,2
]}

Lee, Hyun Chul ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Inst Endocrine Res, Seoul 120752, South Korea

[3] Yonsei Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Dept Pharmacol, Seoul 120752, South Korea

[5] Ewha Womans Univ, Coll Pharm, Seoul, South Korea

[6] Ctr Cell Signaling & Drug Discovery Res, Seoul, South Korea

[7] Yonsei Univ, Coll Med, Dept Chem, Seoul 120752, South Korea

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 579卷 / 1-3期

关键词：

lithospermate; 13; OLETF rats; diabetic nephropathy; oxidative stress; MCP-1; type; 2; diabetes;

D O I：

10.1016/j.ejphar.2007.10.070

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal models. In the present study we investigated the effects of LAB on the prevention of diabetic nephropathy in type 2 diabetic Otsuka Long-Evans-Tokushima Fatty (OLETF) rats. LAB (20 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Treatment of OLETF rats with LAB had little effects on body weight and blood glucose levels. Treatment with LAB resulted in significant reduction in blood pressure. LAB markedly attenuated albumiinuria and significantly lowered levels of lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-p (TGF-beta 1) expression in renal tissues of OLETF rats. In addition, LAB inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. Collectively, these results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing blood pressure, oxidative stress, and MCP-1 expression. Our results suggest that LAB might be a new therapeutic agent for the prevention of nephropathy in type 2 diabetes. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：418 / 425

页数：8

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