Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2

被引:34
作者
Havervall, Sebastian [1 ]
Marking, Ulrika [1 ]
Greilert-Norin, Nina [1 ]
Ng, Henry [1 ,2 ]
Gordon, Max [1 ]
Salomonsson, Ann-Christin [1 ]
Hellstrom, Cecilia [3 ]
Pin, Elisa [3 ]
Blom, Kim [4 ]
Mangsbo, Sara [5 ]
Phillipson, Mia [2 ]
Klingstrom, Jonas [4 ,6 ]
Hober, Sophia [3 ]
Nilsson, Peter [3 ]
Aberg, Mikael [7 ]
Thalin, Charlotte [1 ]
机构
[1] Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden
[2] Uppsala Univ, Dept Med Cell Biol, Sci Life Lab, Uppsala, Sweden
[3] KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, Stockholm, Sweden
[4] Publ Hlth Agcy Sweden, Solna, Sweden
[5] Uppsala Univ, Dept Pharmaceut Biosci, Sci Life Lab, Uppsala, Sweden
[6] Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden
[7] Uppsala Univ, Dept Med Sci, Clin Chem Sci Life Lab, Uppsala, Sweden
来源
EBIOMEDICINE | 2021年 / 70卷
基金
瑞典研究理事会;
关键词
SARS-CoV-2; Neutralizing antibody response; Prior infection; ChAdOx1; nCoV-19; BNT162b2; vaccine;
D O I
10.1016/j.ebiom.2021.103523
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity. Methods: We compared RBD-specific IgG and RBD-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants of concern following two doses of the mRNA vaccine BNT162b2 in SARS-CoV-2 naive healthcare workers (n=65) and a single dose of the adenovector vaccine ChAdOx1 nCoV-19 in 82 healthcare workers more than (n=45) and less than (n=37) 11 months post mild SARS-CoV-2 infection at time of vaccination. Findings: The post-vaccine levels of RBD-specific IgG and neutralizing antibodies against the SARS-CoV-2 wild type and variants of concern including Delta lineage 1.617.2 were similar or higher in participants receiving a single dose of ChAdOx1 nCoV-19 vaccine post SARS-CoV-2 infection (both more than and less than 11 months post infection) compared to SARS-CoV-2 naive participants who received two doses of BNT162b2 vaccine. Interpretation: Our data support that a single dose ChAdOx1 nCoV-19 vaccine that is administered up to at least 11 months post SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen. (C) 2021 The Author(s). Published by Elsevier B.V.
引用
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页数:7
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