Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

被引：97
作者：
Wei, Hao [1 ]
Hu, Yangnan [2 ,3 ]
Wang, Junguo [1 ]
Gao, Xia [1 ]
Qian, Xiaoyun [1 ]
Tang, Mingliang [2 ,3 ,4 ,5 ]
机构：
[1] Nanjing Univ, Jiangsu Prov Key Med Discipline, Affiliated Drum Tower Hosp, Dept Otolaryngol Head & Neck Surg,Med Sch, Nanjing 210008, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Life Sci & Technol, Jiangsu Prov High Tech Key Lab Biomed Res, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
[3] Nantong Univ, Co Innovat Ctr Neuroregenerat, Nantong 226001, Peoples R China
[4] Soochow Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Suzhou 215000, Peoples R China
[5] Soochow Univ, Med Coll, Inst Cardiovasc Sci, Suzhou 215000, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
基金：
中国国家自然科学基金;
关键词：
uperparamagnetic iron oxide nanoparticles; stem cells; cytotoxicity; biological behavior; NEURAL STEM-CELLS; MESENCHYMAL STROMAL CELLS; DRUG-DELIVERY; IN-VITRO; SPIO NANOPARTICLES; MIGRATION; TRACKING; MRI; DIFFERENTIATION; DESIGN;
D O I：
10.2147/IJN.S321984
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.
引用
收藏
页码：6097 / 6113
页数：17
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