2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: A Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis

被引：4
作者：
Das, S. [1 ]
Das, U. [1 ]
Bandy, B. [1 ]
Gorecki, D. K. J. [1 ]
Dimmock, J. R. [1 ]
机构：
[1] Univ Saskatchewan, Coll Pharm & Nutr, Drug Design & Discovery Res Grp, Saskatoon, SK S7N 5C9, Canada
来源：
PHARMAZIE | 2010年 / 65卷 / 11期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1691/ph.2010.0621
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 mu g/mL towards Mycobacterium tuberculosis H(37)Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.
引用
收藏
页码：849 / 850
页数：2
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