Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

被引：25
作者：
Piknova, Barbora [1 ]
Schechter, Alan N. [1 ]
Park, Ji Won [1 ]
Vanhatalo, Anni [2 ]
Jones, Andrew M. [2 ]
机构：
[1] NIDDK, Mol Med Branch, NIH, Bethesda, MD 20892 USA
[2] Univ Exeter, Coll Life & Environm Sci, Sport & Hlth Sci, Heavitree Rd, Exeter EX1 2LU, Devon, England
来源：
EXERCISE AND SPORT SCIENCES REVIEWS | 2022年 / 50卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 美国国家卫生研究院;
关键词：
nitrate; nitrite; nitric oxide; skeletal muscle; exercise; health; xanthine oxidoreductase; BEETROOT JUICE SUPPLEMENTATION; DIETARY NITRATE; MITOCHONDRIAL EFFICIENCY; MYOGLOBIN DESATURATION; METABOLIC-RESPONSES; REDUCTASE-ACTIVITY; INORGANIC NITRATE; VEGETABLE INTAKE; OXYGEN; EXERCISE;
D O I：
10.1249/JES.0000000000000272
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.
引用
收藏
页码：2 / 13
页数：12
相关论文
共 50 条
  • [31] Nitric oxide contributes to the regulation of iron metabolism in skeletal muscle in vivo and in vitro
    Haitao Wang
    Xianglin Duan
    Jianguo Liu
    Huanbin Zhao
    Yuqian Liu
    Yanzhong Chang
    Molecular and Cellular Biochemistry, 2010, 342 : 87 - 94
  • [32] POTENTIAL ROLE OF NITRIC OXIDE IN CONTRACTION-STIMULATED GLUCOSE UPTAKE AND MITOCHONDRIAL BIOGENESIS IN SKELETAL MUSCLE
    McConell, Glenn K.
    Wadley, Glenn D.
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2008, 35 (12): : 1488 - 1492
  • [33] Nitric oxide in skeletal muscle: Inhibition of nitric oxide synthase inhibits walking speed in rats
    Wang, MX
    Murrell, DF
    Szabo, C
    Warren, RF
    Sarris, M
    Murrell, GAC
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2001, 5 (03): : 219 - 232
  • [34] Nitric oxide contributes to the regulation of iron metabolism in skeletal muscle in vivo and in vitro
    Wang, Haitao
    Duan, Xianglin
    Liu, Jianguo
    Zhao, Huanbin
    Liu, Yuqian
    Chang, Yanzhong
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2010, 342 (1-2) : 87 - 94
  • [35] Skeletal muscle as an endogenous nitrate reservoir
    Piknova, Barbora
    Park, Ji Won
    Swanson, Kathryn M.
    Dey, Soumyadeep
    Noguchi, Constance Tom
    Schechter, Alan N.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 47 : 10 - 16
  • [36] Relationships between nitric oxide biomarkers and physiological outcomes following dietary nitrate supplementation
    Wei, Chenguang
    Vanhatalo, Anni
    Black, Matthew I.
    Blackwell, Jamie R.
    Rajaram, Raghini
    Kadach, Stefan
    Jones, Andrew M.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2024, 148 : 23 - 33
  • [37] Nitrate Supplementation Enhances the Contractile Properties of Human Skeletal Muscle
    Haider, Georg
    Folland, Jonathan P.
    MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2014, 46 (12) : 2234 - 2243
  • [38] Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
    Coggan, Andrew R.
    Peterson, Linda R.
    EXERCISE AND SPORT SCIENCES REVIEWS, 2018, 46 (04): : 254 - 261
  • [39] Nitric oxide in the regulation of vasomotor tone in human skeletal muscle
    Rådegran, G
    Saltin, B
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 276 (06): : H1951 - H1960
  • [40] Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism
    Tom Ashmore
    Lee D. Roberts
    Andrea J. Morash
    Aleksandra O. Kotwica
    John Finnerty
    James A. West
    Steven A. Murfitt
    Bernadette O. Fernandez
    Cristina Branco
    Andrew S. Cowburn
    Kieran Clarke
    Randall S. Johnson
    Martin Feelisch
    Julian L. Griffin
    Andrew J. Murray
    BMC Biology, 13
12345