Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

被引：25

作者：

Piknova, Barbora ^{[1
]}

Schechter, Alan N. ^{[1
]}

Park, Ji Won ^{[1
]}

Vanhatalo, Anni ^{[2
]}

Jones, Andrew M. ^{[2
]}

机构：

[1] NIDDK, Mol Med Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Exeter, Coll Life & Environm Sci, Sport & Hlth Sci, Heavitree Rd, Exeter EX1 2LU, Devon, England

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2022年 / 50卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

nitrate; nitrite; nitric oxide; skeletal muscle; exercise; health; xanthine oxidoreductase; BEETROOT JUICE SUPPLEMENTATION; DIETARY NITRATE; MITOCHONDRIAL EFFICIENCY; MYOGLOBIN DESATURATION; METABOLIC-RESPONSES; REDUCTASE-ACTIVITY; INORGANIC NITRATE; VEGETABLE INTAKE; OXYGEN; EXERCISE;

D O I：

10.1249/JES.0000000000000272

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

引用

页码：2 / 13

页数：12

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