Mechanisms of FLASH effect

被引：30

作者：

Lin, Binwei ^{[1
,2
]}

Huang, Dan ^{[3
]}

Gao, Feng ^{[1
]}

Yang, Yiwei ^{[4
]}

Wu, Dai ^{[4
]}

Zhang, Yu ^{[1
]}

Feng, Gang ^{[1
]}

Dai, Tangzhi ^{[1
]}

Du, Xiaobo ^{[1
]}

机构：

[1] Mianyang Cent Hosp, Natl Hlth Commiss NHC Key Lab Nucl Technol Med Tra, Dept Oncol, Mianyang, Peoples R China

[2] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China

[3] Mianyang Cent Hosp, Dept Radiol, Mianyang, Peoples R China

[4] China Acad Engn Phys, Inst Appl Elect, Mianyang, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

FLASH radiotherapy; conventional dose-rate radiotherapy; mechanism; oxygen; radiobiology; HIGH-DOSE-RATE; BLOOD-BRAIN-BARRIER; RADIATION-THERAPY; IRRADIATION; RADIOTHERAPY; CELLS; TOXICITY; OUTCOMES; PULSES; RATES;

D O I：

10.3389/fonc.2022.995612

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (>= 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions.

引用

页数：8

共 61 条

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