Mechanisms of FLASH effect

被引:23
作者
Lin, Binwei [1 ,2 ]
Huang, Dan [3 ]
Gao, Feng [1 ]
Yang, Yiwei [4 ]
Wu, Dai [4 ]
Zhang, Yu [1 ]
Feng, Gang [1 ]
Dai, Tangzhi [1 ]
Du, Xiaobo [1 ]
机构
[1] Mianyang Cent Hosp, Natl Hlth Commiss NHC Key Lab Nucl Technol Med Tra, Dept Oncol, Mianyang, Peoples R China
[2] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China
[3] Mianyang Cent Hosp, Dept Radiol, Mianyang, Peoples R China
[4] China Acad Engn Phys, Inst Appl Elect, Mianyang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词
FLASH radiotherapy; conventional dose-rate radiotherapy; mechanism; oxygen; radiobiology; HIGH-DOSE-RATE; BLOOD-BRAIN-BARRIER; RADIATION-THERAPY; IRRADIATION; RADIOTHERAPY; CELLS; TOXICITY; OUTCOMES; PULSES; RATES;
D O I
10.3389/fonc.2022.995612
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (>= 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions.
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页数:8
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