The trifluoroethylamine function as peptide bond replacement

[1] The consequences of lysosomotropism on the design of selective cathepsin K inhibitors [J]. CHEMBIOCHEM, 2006, 7 (10) : 1525 - 1535

[2] Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (21) : 4741 - 4744

[3] Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (06) : 1210 - 1219

[4] STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF TEMPERATURE-DEPENDENT CHANGES IN THE FOLDING PATTERN OF A SYNTHETIC TRIAMIDE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) : 4228 - 4245

[5] Organic fluorine hardly ever accepts hydrogen bonds [J]. CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (01) : 89 - 98

[6] Partially modified retro-inverso peptides: Development, synthesis, and conformational behavior [J]. CHEMICAL REVIEWS, 1998, 98 (02) : 763 - 795

[7] NEW THIOL INHIBITORS OF NEUTRAL ENDOPEPTIDASE EC-3.4.24.11 - SYNTHESIS AND ENZYME ACTIVE-SITE RECOGNITION [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) : 1865 - 1873

[8] Stereochemical requirements for beta-hairpin formation: Model studies with four-residue peptides and depsipeptides [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (29) : 6975 - 6985

[9] Hughes G., 2007, ANGEW CHEM, V119, P1871

[10] Diastereoselective reductive Amination of aryl trifluoromethyl ketones and α-amino esters [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (11) : 1839 - 1842

[1] The consequences of lysosomotropism on the design of selective cathepsin K inhibitors [J]. CHEMBIOCHEM, 2006, 7 (10) : 1525 - 1535

[2] Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (21) : 4741 - 4744

[3] Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (06) : 1210 - 1219

[4] STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF TEMPERATURE-DEPENDENT CHANGES IN THE FOLDING PATTERN OF A SYNTHETIC TRIAMIDE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) : 4228 - 4245

[5] Organic fluorine hardly ever accepts hydrogen bonds [J]. CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (01) : 89 - 98

[6] Partially modified retro-inverso peptides: Development, synthesis, and conformational behavior [J]. CHEMICAL REVIEWS, 1998, 98 (02) : 763 - 795

[7] NEW THIOL INHIBITORS OF NEUTRAL ENDOPEPTIDASE EC-3.4.24.11 - SYNTHESIS AND ENZYME ACTIVE-SITE RECOGNITION [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) : 1865 - 1873

[8] Stereochemical requirements for beta-hairpin formation: Model studies with four-residue peptides and depsipeptides [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (29) : 6975 - 6985

[9] Hughes G., 2007, ANGEW CHEM, V119, P1871

[10] Diastereoselective reductive Amination of aryl trifluoromethyl ketones and α-amino esters [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (11) : 1839 - 1842