Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy

被引:7
作者
Juan, Yun-Ting [1 ]
Chiang, Wen-Chih [2 ]
Lin, Wei-Chou [3 ]
Yang, Cheng-Wen [1 ]
Chou, San-Fang [4 ]
Hung, Ruo-Wei [1 ]
Chiu, Yen-Ling [1 ,4 ,5 ,6 ,7 ]
机构
[1] Far Eastern Mem Hosp, Dept Nephrol, New Taipei 220, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Med, Div Nephrol, Taipei 100, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan
[4] Far Eastern Mem Hosp, Dept Med Res, New Taipei 220, Taiwan
[5] Yuan Ze Univ, Grad Inst Med, Taoyuan 320, Taiwan
[6] Yuan Ze Univ, Grad Program Biomed Informat, Taoyuan 320, Taiwan
[7] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei 100, Taiwan
关键词
complement C5a; factor Ba; galactose-deficient IgA1; IgA nephropathy; Oxford classification;
D O I
10.3390/jcm11144231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.
引用
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页数:11
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