Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy

被引:7
作者
Juan, Yun-Ting [1 ]
Chiang, Wen-Chih [2 ]
Lin, Wei-Chou [3 ]
Yang, Cheng-Wen [1 ]
Chou, San-Fang [4 ]
Hung, Ruo-Wei [1 ]
Chiu, Yen-Ling [1 ,4 ,5 ,6 ,7 ]
机构
[1] Far Eastern Mem Hosp, Dept Nephrol, New Taipei 220, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Med, Div Nephrol, Taipei 100, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan
[4] Far Eastern Mem Hosp, Dept Med Res, New Taipei 220, Taiwan
[5] Yuan Ze Univ, Grad Inst Med, Taoyuan 320, Taiwan
[6] Yuan Ze Univ, Grad Program Biomed Informat, Taoyuan 320, Taiwan
[7] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei 100, Taiwan
关键词
complement C5a; factor Ba; galactose-deficient IgA1; IgA nephropathy; Oxford classification;
D O I
10.3390/jcm11144231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.
引用
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页数:11
相关论文
共 24 条
[11]   Current Understanding of the Role of Complement in IgA Nephropathy [J].
Maillard, Nicolas ;
Wyatt, Robert J. ;
Julian, Bruce A. ;
Kiryluk, Krzysztof ;
Gharavi, Ali ;
Fremeaux-Bacchi, Veronique ;
Novak, Jan .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (07) :1503-1512
[12]   Updated Oxford Classification of IgA nephropathy: a new MEST-C score [J].
Markowitz, Glen .
NATURE REVIEWS NEPHROLOGY, 2017, 13 (07) :385-386
[13]   Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels [J].
Moldoveanu, Z. ;
Wyatt, R. J. ;
Lee, J. Y. ;
Tomana, M. ;
Julian, B. A. ;
Mestecky, J. ;
Huang, W-Q ;
Anreddy, S. R. ;
Hall, S. ;
Hastings, M. C. ;
Lau, K. K. ;
Cook, W. J. ;
Novak, J. .
KIDNEY INTERNATIONAL, 2007, 71 (11) :1148-1154
[14]   Updated Oxford classification of IgA nephropathy: expanding scope of the schema [J].
Mubarak, Muhammed .
JOURNAL OF RENAL INJURY PREVENTION, 2018, 7 (02) :53-55
[15]   Higher serum galactose-deficient immunoglobulin A1 concentration is associated with stronger mesangial cellular inflammatory response and more severe histologic findings in immunoglobulin A nephropathy [J].
Nguyen, Celine ;
Koenig, Katrin ;
Tam, Frederick W. K. ;
Hopfer, Helmut ;
Molyneux, Karen ;
Binet, Francoise-Isabelle ;
Kim, Min Jeong .
CLINICAL KIDNEY JOURNAL, 2019, 12 (02) :232-238
[16]   The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy [J].
Rizk, Dana V. ;
Maillard, Nicolas ;
Julian, Bruce A. ;
Knoppova, Barbora ;
Green, Todd J. ;
Novak, Jan ;
Wyatt, Robert J. .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[17]   Pathological predictors of prognosis in immunoglobulin A nephropathy: a review [J].
Roufosse, Candice A. ;
Cook, H. Terence .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2009, 18 (03) :212-219
[18]   Biomarkers and Precision Medicine in IgA Nephropathy [J].
Schena, Francesco Paolo ;
Cox, Sharon Natasha .
SEMINARS IN NEPHROLOGY, 2018, 38 (05) :521-530
[19]   Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis [J].
Suzuki, Hitoshi .
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2019, 23 (01) :26-31
[20]   Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group [J].
Trimarchi, Hernan ;
Barratt, Jonathan ;
Cattran, Daniel C. ;
Cook, H. Terence ;
Coppo, Rosanna ;
Haas, Mark ;
Liu, Zhi-Hong ;
Roberts, Ian S. D. ;
Yuzawa, Yukio ;
Zhang, Hong ;
Feehally, John .
KIDNEY INTERNATIONAL, 2017, 91 (05) :1014-1021