Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy

被引:7
|
作者
Juan, Yun-Ting [1 ]
Chiang, Wen-Chih [2 ]
Lin, Wei-Chou [3 ]
Yang, Cheng-Wen [1 ]
Chou, San-Fang [4 ]
Hung, Ruo-Wei [1 ]
Chiu, Yen-Ling [1 ,4 ,5 ,6 ,7 ]
机构
[1] Far Eastern Mem Hosp, Dept Nephrol, New Taipei 220, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Med, Div Nephrol, Taipei 100, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan
[4] Far Eastern Mem Hosp, Dept Med Res, New Taipei 220, Taiwan
[5] Yuan Ze Univ, Grad Inst Med, Taoyuan 320, Taiwan
[6] Yuan Ze Univ, Grad Program Biomed Informat, Taoyuan 320, Taiwan
[7] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei 100, Taiwan
关键词
complement C5a; factor Ba; galactose-deficient IgA1; IgA nephropathy; Oxford classification;
D O I
10.3390/jcm11144231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA1 Antibody in IgA Nephropathy Patients
    Chiu, Yen-Ling
    Lin, Wei-Chou
    Shu, Kai-Hsiang
    Fang, Yi-Wen
    Chang, Fan-Chi
    Chou, Yu-Hsiang
    Wu, Ching-Fang
    Chiang, Wen-Chih
    Lin, Shuei-Liong
    Chen, Yung-Ming
    Wu, Ming-Shiou
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [2] Pathogenic potential of galactose-deficient IgA1 in IgA nephropathy
    Mestecky, J
    Novak, J
    Julian, BA
    Tomana, M
    NEPHROLOGY, 2002, 7 : S92 - S99
  • [3] Galactose-Deficient IgA1 as a Candidate Urinary Marker of IgA Nephropathy
    Fukao, Yusuke
    Suzuki, Hitoshi
    Kim, Jin Sug
    Jeong, Kyung Hwan
    Makita, Yuko
    Kano, Toshiki
    Nihei, Yoshihito
    Nakayama, Maiko
    Lee, Mingfeng
    Kato, Rina
    Chang, Jer-Ming
    Lee, Sang Ho
    Suzuki, Yusuke
    JOURNAL OF CLINICAL MEDICINE, 2022, 11 (11)
  • [4] Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis
    Tang, Mengmeng
    Zhang, Xue
    Li, Xueqian
    Lei, Lei
    Zhang, Hejia
    Ling, Chen
    Ni, Jie
    Lv, Jicheng
    Liu, Xiaorong
    Chen, Xiangmei
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2021, 25 (01) : 37 - 43
  • [5] Plasma Galactose-Deficient IgA1 and C3 and CKD Progression in IgA Nephropathy
    Chen, Pei
    Yu, Guizhen
    Zhang, Xue
    Xie, Xinfang
    Wang, Jinwei
    Shi, Sufang
    Liu, Lijun
    Lv, Jicheng
    Zhang, Hong
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2019, 14 (10): : 1458 - 1465
  • [6] The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression
    Zhao, Na
    Hou, Ping
    Lv, Jicheng
    Moldoveanu, Zina
    Li, Yifu
    Kiryluk, Krzysztof
    Gharavi, Ali G.
    Novak, Jan
    Zhang, Hong
    KIDNEY INTERNATIONAL, 2012, 82 (07) : 790 - 796
  • [7] Clinical Significance of the Intensity of Glomerular Galactose-Deficient IgA1 Deposition in IgA Nephropathy
    Nakayama, Maiko
    Suzuki, Hitoshi
    Fukao, Yusuke
    Lee, Mingfeng
    Kano, Toshiki
    Suzuki, Yusuke
    KIDNEY INTERNATIONAL REPORTS, 2022, 7 (12): : 2726 - 2729
  • [8] Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG
    Tomana, M
    Matousovic, K
    Julian, BA
    Radl, J
    Konecny, K
    Mestecky, J
    KIDNEY INTERNATIONAL, 1997, 52 (02) : 509 - 516
  • [9] Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease
    Reily, Colin
    Ueda, Hiroyuki
    Huang, Zhi-Qiang
    Mestecky, Jiri
    Julian, Bruce A.
    Willey, Christopher D.
    Novak, Jan
    JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014
  • [10] Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels
    Moldoveanu, Z.
    Wyatt, R. J.
    Lee, J. Y.
    Tomana, M.
    Julian, B. A.
    Mestecky, J.
    Huang, W-Q
    Anreddy, S. R.
    Hall, S.
    Hastings, M. C.
    Lau, K. K.
    Cook, W. J.
    Novak, J.
    KIDNEY INTERNATIONAL, 2007, 71 (11) : 1148 - 1154