Insulin signaling in the heart

被引：53

作者：

Abel, E. Dale ^{[1
,2
]}

机构：

[1] Univ Iowa, Carver Coll Med, Div Endocrinol Metab & Diabet, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2021年 / 321卷 / 01期

基金：

美国国家卫生研究院;

关键词：

heart; insulin; metabolism; signal transduction; FATTY-ACID OXIDATION; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; CARDIAC-SPECIFIC OVEREXPRESSION; DIET-INDUCED OBESITY; IN-VITRO MODEL; GLUCOSE-UPTAKE; CIRCADIAN CLOCK; CONTRACTILE DYSFUNCTION; DIABETIC CARDIOMYOPATHY;

D O I：

10.1152/ajpendo.00158.2021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial metabolism. Insulin signaling modulates the cardiac responses to physiological and pathological stressors. Altered insulin signaling in the heart may contribute to the pathophysiology of ventricular remodeling and heart failure progression. Myocardial insulin signaling adapts rapidly to changes in the systemic metabolic milieu. What may initially represent an adaptation to protect the heart from carbotoxicity may contribute to amplifying the risk of heart failure in obesity and diabetes. This review article presents the multiple roles of insulin signaling in cardiac physiology and pathology and discusses the potential therapeutic consequences of modulating myocardial insulin signaling.

引用

页码：E130 / E145

页数：16

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