Making a tumour's bed: glioblastoma stem cells and the vascular niche

被引：550

作者：

Gilbertson, Richard J.

Rich, Jeremy N.

机构：

[1] St Jude Childrens Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] St Jude Childrens Hosp, Dept Oncol, Memphis, TN 38105 USA

[3] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 10期

关键词：

D O I：

10.1038/nrc2246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Parallel to the role that normal stem cells play in organogenesis, cancer stem cells are thought to be crucial for tumorigenesis. Understanding normal development might therefore lead to better treatments of cancer. We review recent data that stem cells of glioblastoma, a highly malignant brain tumour, seem to be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. These data have direct implications for cancer, highlighting the similarity between normal and malignant stem cells and identifying the tumour microenvironment as a target for new therapies.

引用

页码：733 / 736

页数：4

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