Transforming Growth Factor-Beta Family: Advances in Vascular Function and Signaling

被引:12
作者
Gatica, Sebastian [1 ,2 ]
Cabello-Verrugio, Claudio [2 ,3 ,4 ]
Simon, Felipe [1 ,2 ,4 ]
机构
[1] Univ Andres Bello, Lab Integrat Physiopathol, Dept Ciencias Biol, Fac Ciencias Biol, 239 Republ Ave, Santiago 8370134, Chile
[2] Univ Andres Bello, Fac Med, 239 Republ Ave, Santiago 8370134, Chile
[3] Univ Andres Bello, Lab Muscle Pathol Fragil & Aging, Dept Ciencias Biol, Fac Ciencias Biol, Santiago, Chile
[4] Millennium Inst Immunol & Immunotherapy, Santiago, Chile
关键词
TGF; vascular; angiogenesis; hypertension; EndMT; fibrosis; TO-MESENCHYMAL TRANSITION; ENDOTHELIAL-CELLS; PROMOTES ANGIOGENESIS; FIBROSIS; GENE; MECHANISMS; TGF-BETA-2; EXPRESSION; BINDING; MURINE;
D O I
10.2174/1389203719666171128114730
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review includes a comprehensive, but succinct, summary on the essentials of TGF-beta structure, family members, receptors, and intracellular mediators. Also provided is a select list of original publications that report novel roles and facets of TGF-beta in vascular function and signaling in the contexts of health and disease.
引用
收藏
页码:1164 / 1171
页数:8
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