Resistance reported from China antimicrobial surveillance network (CHINET) in 2018

被引：271

作者：

Hu, Fupin ^{[1
,2
]}

Guo, Yan ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Zheng, Yonggui ^{[1
,2
]}

Wu, Shi ^{[1
,2
]}

Jiang, Xiaofei ^{[3
]}

Zhu, Demei ^{[1
,2
]}

Wang, Fu ^{[1
,2
]}

Xu, Yingchun ^{[4
]}

Zhang, Xiaojiang ^{[4
]}

Zhang, Zhaoxia ^{[5
]}

Ji, Ping ^{[5
]}

Kang, Mei ^{[6
]}

He, Chao ^{[6
]}

Wang, Chuanqing ^{[7
]}

He, Leiyan ^{[7
]}

Xu, Yuanhong ^{[8
,13
]}

Huang, Ying ^{[8
]}

Chen, Zhongju ^{[9
]}

Sun, Ziyong ^{[9
]}

Ni, Yuxing ^{[10
]}

Sun, Jingyong ^{[10
]}

Chu, Yunzhuo ^{[11
]}

Tian, Sufei ^{[11
]}

Hu, Zhidong ^{[12
]}

Li, Jin ^{[12
]}

Yu, Yunsong ^{[13
]}

Lin, Jie ^{[13
]}

Shan, Bin ^{[14
]}

Du, Yan ^{[14
]}

Guo, Sufang ^{[15
]}

Wang, Yanyan ^{[15
]}

Wei, Lianhua ^{[16
]}

Wang, Xin ^{[16
]}

Zhang, Hong ^{[17
]}

Wang, Chun ^{[17
]}

Hu, Yunjian ^{[18
]}

Ai, Xiaoman ^{[18
]}

Zhuo, Chao ^{[19
]}

Su, Danhong ^{[19
]}

Wang, Ruizhong ^{[20
]}

Fang, Hua ^{[20
]}

Yu, Bixia ^{[21
]}

Gong, Ping ^{[22
]}

Song, Miao ^{[22
]}

Guo, Dawen ^{[23
]}

Zhao, Jinying ^{[23
]}

Liu, Wen'en ^{[24
]}

Li, Yanming ^{[24
]}

Jin, Yan ^{[25
]}

机构：

[1] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai, Peoples R China

[2] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China

[3] Fudan Univ, Huashan Hosp, Lab Med, Shanghai, Peoples R China

[4] Peking Union Med Coll Hosp, Beijing, Peoples R China

[5] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi, Peoples R China

[6] Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China

[7] Fudan Univ, Childrens Hosp, Shanghai, Peoples R China

[8] Anhui Med Univ, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[9] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Hubei, Peoples R China

[10] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai, Peoples R China

[11] China Med Univ, Affiliated Hosp 1, Taichung, Taiwan

[12] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China

[13] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China

[14] Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China

[15] Inner Mongolia Med Univ, Affiliated Hosp 1, Hohhot, Mongolia

[16] Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China

[17] Childrens Hosp Shanghai, Shanghai, Peoples R China

[18] Beijing Hosp, Beijing, Peoples R China

[19] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[20] Pudong New Area Peoples Hosp, Shanghai, Peoples R China

[21] Zhejiang Ningbo Zhenhai Longsai Hosp, Ningbo, Zhejiang, Peoples R China

[22] Peoples Hosp Zigui, Yichang, Hubei, Peoples R China

[23] Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China

[24] Cent South Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China

[25] Shandong Prov Hosp, Jinan, Shandong, Peoples R China

[26] Jinjiang Municipal Hosp, Jinjiang, Peoples R China

[27] Jilin Univ, China Japan Union Hosp, Changchun, Jilin, Peoples R China

[28] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China

[29] Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China

[30] Shaanxi Prov Peoples Hosp, Xian, Shaanxi, Peoples R China

[31] Jiangxi Prov Childrens Hosp, Nanchang, Jiangxi, Peoples R China

[32] Childrens Hosp Shanxi, Taiyuan, Shanxi, Peoples R China

[33] Capital Med Univ, Beijing Childrens Hosp, Beijing, Peoples R China

[34] Nanjing Drum Tower Hosp, Affiliated Hosp Nanjing, Nanjing, Jiangsu, Peoples R China

[35] Ningxia Med Univ, Gen Hosp, Yinchuan, Peoples R China

[36] Shenzhen Peoples Hosp, Shenzhen, Peoples R China

[37] Hebei Med Univ, Hosp 2, Shijiazhuang, Hebei, Peoples R China

[38] Jinchang Hosp Integrated Tradit Chinese & Western, Wuwei, Gansu, Peoples R China

[39] Peoples Hosp Ganxian, Nanning, Peoples R China

[40] Guangrao Cty Peoples Hosp, Dongying, Peoples R China

[41] Peoples Hosp Huixian, Zhengzhou, Henan, Peoples R China

[42] Cent Hosp Yingkou Dev Zone, Yingkou, Liaoning, Peoples R China

[43] Huzhu Cty Peoples Hosp, Xining, Qinghai, Peoples R China

[44] Peoples Hosp Linshui, Chengdu, Sichuan, Peoples R China

[45] Lixin Cty Peoples Hosp, Bozhou, Peoples R China

[46] Jiutai Peoples Hosp, Changchun, Jilin, Peoples R China

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2019年 / 38卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Bacterial resistance surveillance; Antimicrobial susceptibility testing; Methicillin-resistant Staphylococcus; Carbapenem-resistant gram-negative bacilli;

D O I：

10.1007/s10096-019-03673-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study is to investigate the antimicrobial susceptibility of strains isolated from the major hospitals in China. A total of 44 teaching hospitals were involved. Antimicrobial susceptibility testing was conducted by Kirby-Bauer automated systems, and results were interpreted using CLSI criteria. Totally 244,843 strains were isolated in 2018, of which gram-negative bacilli and gram-positive cocci were accounting for 71.8% and 28.2%, respectively. 39.7% of isolates were cultured from lower respiratory tract, 18.8% from urine, 14.8% from blood, 1.3% from cerebrospinal fluid, respectively. Of those, the five major species were most often isolated (65.5%, 63%, 52.3%, and 30.3%). The resistance rate of MRSA to most antimicrobial agents was significantly higher than that of MSSA strains, except for to trimethoprim-sulfamethoxazole in urine specimen. E.coli was still highly susceptible to carbapenem antibiotics, and the resistance rate was less than 5%. Carbapenem resistance among Klebsiella pneumoniae, especially cultured from cerebrospinal fluid, increased significance from 18.6 to 64.1%. The resistance rates of Pseudomonas aeruginosa to carbapenems were nearly 30% in the blood, in urine, and in the lower respiratory tract, but about 60% of that in cerebrospinal fluid. About 80% of Acinetobacter baumannii strains was resistant to imipenem and meropenem, respectively. Bacterial resistance of five major clinical isolates from cerebrospinal fluid to common antibiotics (in particular Carbapenem-resistant Klebsiella pneumoniae) currently shows an increasing trend. It is worth to emphasize the importance of serious control of hospital infection and better management of clinical use of antimicrobial agents.

引用

页码：2275 / 2281

页数：7

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