Homoisoflavonoids from the tuberous roots of Ophiopogon japonicus with their cytotoxic activities

被引：7

作者：

Chen, Ying ^{[2
]}

Chai, Jin-Xuan ^{[1
]}

Li, Li ^{[1
]}

Sun, Ji-Kai ^{[1
]}

Guo, Li -Na ^{[1
]}

Wang, Xiao-Li ^{[1
]}

Dong, Wei ^{[1
]}

Xu, Ji-Feng ^{[3
]}

Zhang, Chun-Jing ^{[2
]}

Song, Bo ^{[1
]}

机构：

[1] Qiqihar Med Univ, Pharm Sch, Qiqihar 161006, Peoples R China

[2] Qiqihar Med Univ, Med Technol Dept, Qiqihar 161006, Peoples R China

[3] Shanghai Stand Technol Co Ltd, Shanghai, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 44卷

关键词：

Ophiopogon japonicus; Homosioflavonoids; Ophiopogonanone I; Methylophiopogonanone C; Cytotoxic activities; GLYCOSIDES;

D O I：

10.1016/j.phytol.2021.05.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new homosioflavonoids, ophiopogonanone I (1) and methylophiopogonanone C (2) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compounds 1 and 2 were assigned on the basis of CD method. In addition, compounds 1-2 were tested for their cytotoxic activities against HL-60, SMMC-7721, and MCF-7 human cancer cell lines, and compound 2 showed significant cytotoxic activity against HL-60 cell line with IC50 value of 14.42 mu M.

引用

页码：31 / 34

页数：4

共 13 条

[1] TERPENOID GLYCOSIDES FROM OPHIOPOGON-JAPONICUS ROOTS [J].

ADINOLFI, M ;

PARRILLI, M ;

ZHU, YX .

PHYTOCHEMISTRY, 1990, 29 (05) :1696-1699

[2] Five new homoisoflavonoids from the tuber of Ophiopogon japonicus [J].

Chang, JM ;

Shen, CC ;

Huang, YL ;

Chien, MY ;

Ou, JC ;

Shieh, BJ ;

Chen, CC .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (11) :1731-1733

[3] Steroidal glycosides from tubers of Ophiopogon japonicus [J].

Cheng, Z. -H. ;

Wu, T. ;

Yu, B. -Y. .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, 8 (06) :555-559

[4] cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus [J].

Cheng, ZH ;

Wu, T ;

Bligh, SWA ;

Bashall, A ;

Yu, BY .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (10) :1761-1763

[5] USE OF AN AQUEOUS SOLUBLE TETRAZOLIUM FORMAZAN ASSAY FOR CELL-GROWTH ASSAYS IN CULTURE [J].

CORY, AH ;

OWEN, TC ;

BARLTROP, JA ;

CORY, JG .

CANCER COMMUNICATIONS, 1991, 3 (07) :207-212

[6] Homoisoflavonoids profiling of Ophiopogon japonicus by off-line coupling high-speed countercurrent chromatography with high-performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry [J].

Deng, Xu ;

Xu, Jinju ;

Tong, Chaoying ;

Shi, Fangying ;

Shi, Shuyun .

JOURNAL OF SEPARATION SCIENCE, 2020, 43 (08) :1406-1414

[7] Spirostanol Saponins from the Fibrous Roots of Ophiopogon japonicus (THUNB.) KER-GAWL [J].

Duan, Chang-Ling ;

Li, Yu-Juan ;

Li, Peng ;

Jiang, Yong ;

Liu, Jian-Xun ;

Tu, Peng-Fei .

HELVETICA CHIMICA ACTA, 2010, 93 (02) :227-232

[8] Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus [J].

Li, Ning ;

Zhang, Jia-Yu ;

Zeng, Ke-Wu ;

Zhang, Liang ;

Che, Yan-Yun ;

Tu, Peng-Fei .

FITOTERAPIA, 2012, 83 (06) :1042-1045

[9]

NAMIKOSHI M, 1987, CHEM PHARM BULL, V35, P3597

[10]

REED L. J., 1938, AMER JOUR HYG, V27, P493

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