Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors

被引：41

作者：

Gurung, Prajwal ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, 262 Danny Thomas Pl, Memphis, TN 38105 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2016年 / 73卷 / 16期

关键词：

NLR; Inflammasome; Parasites; Protozoa; NOD; NLRP3; TRYPANOSOMA-CRUZI INFECTION; CD8(+) T-CELLS; INDUCIBLE NITRIC-OXIDE; ENDOGENOUS IFN-GAMMA; AMEBIC LIVER-ABSCESS; NF-KAPPA-B; ENTAMOEBA-HISTOLYTICA INFECTION; LEISHMANIA-MAJOR AMASTIGOTES; TOXOPLASMA-GONDII INFECTION; INNATE IMMUNITY;

D O I：

10.1007/s00018-016-2212-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nod-like receptors (NLRs) have gained attention in recent years because of the ability of some family members to assemble into a multimeric protein complex known as the inflammasome. The role of NLRs and the inflammasome in regulating innate immunity against bacterial pathogens has been well studied. However, recent studies show that NLRs and inflammasomes also play a role during infections caused by protozoan parasites, which pose a significant global health burden. Herein, we review the diseases caused by the most common protozoan parasites in the world and discuss the roles of NLRs and inflammasomes in host immunity against these parasites.

引用

页码：3035 / 3051

页数：17

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