Acquired Hemophilia A in Peripartum Period: Diagnostic and Therapeutic Dilemma

被引：3

作者：

Bin Waqar, Syed Hamza ^{[1
]}

Khoury, Leen ^{[1
]}

Hussain, Ather ^{[2
]}

McFarlane, Isabel M. ^{[3
]}

机构：

[1] Suny Downstate Med Ctr, Hematol & Oncol, New York, NY 11203 USA

[2] Rochester Gen Hosp, Hematol & Oncol, Rochester, NY 14621 USA

[3] Suny Downstate Med Ctr, Internal Med, New York, NY USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 08期

关键词：

acquired hemophilia a; factor viii; hemophilia; aptt; peripartum; aha; INHIBITORS;

D O I：

10.7759/cureus.16803

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acquired hemophilia A (AHA) is a bleeding diathesis caused by auto-antibody generation against factor VIII, an essential component of the coagulation cascade. Although having many etiologies, pregnancy is also one of the conditions associated with AHA. It mostly presents as a raised activated partial thromboplastin time (aPTT), and during the peripartum and postpartum period, concern for AHA should be raised as delays in diagnosis can be detrimental. Herein, we present a case of a 31-year-old female with sickle cell trait who developed venous bleeding and, later, neuraxial, musculoskeletal, and subcutaneous bleeding. She underwent an extensive course of treatment before getting into remission.

引用

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