Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy

被引：139

作者：

Tang, Zhong-min ^{[1
,2
]}

Liu, Yan-yan ^{[3
]}

Ni, Da-long ^{[2
]}

Zhou, Jia-jia ^{[4
]}

Zhang, Meng ^{[2
]}

Zhao, Pei-ran ^{[3
]}

Lv, Bin ^{[5
]}

Wang, Han ^{[2
]}

Jin, Da-yong ^{[4
]}

Bu, Wen-bo ^{[1
,2
,3
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[3] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[4] Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, Sydney, NSW 2007, Australia

[5] Fudan Univ, Huadong Hosp, Dept Radiotherapy, Shanghai 200040, Peoples R China

来源：

ADVANCED MATERIALS | 2020年 / 32卷 / 04期

基金：

国家重点研发计划; 美国国家科学基金会; 中国国家自然科学基金;

关键词：

biodegradable nanoprodrugs; MgO2; nanosheets; molecular dynamic therapy; tumor microenvironment; REACTIVE OXYGEN; HYDROGEN-PEROXIDE; GROWTH; TRANSDUCTION; MAGNESIUM;

D O I：

10.1002/adma.201904011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic center dot OH to kill tumor cells.

引用

页数：7

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