Impact of diabetes mellitus on long-term prognosis after gastrectomy for advanced gastric cancer: a propensity score matching analysis

被引:2
作者
Matsui, Ryota [1 ,2 ]
Inaki, Noriyuki [1 ,3 ]
Tsuji, Toshikatsu [1 ]
机构
[1] Ishikawa Prefectural Cent Hosp, Dept Gastroenterol Surg, Kanazawa, Ishikawa, Japan
[2] Juntendo Univ, Dept Surg, Urayasu Hosp, Urayasu, Japan
[3] Kanazawa Univ, Grad Sch Med Sci, Dept Gastrointestinal Surg Breast Surg, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan
关键词
Diabetes mellitus; Gastric cancer; Overall survival; Prognosis; Skeletal muscle mass; POSTOPERATIVE WEIGHT-LOSS; RISK-FACTOR; METAANALYSIS; OBESITY; DISEASE; CHEMOTHERAPY; SURVIVAL; PARADOX;
D O I
10.1007/s00595-022-02482-y
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose We investigated the long-term prognostic impact of diabetes mellitus (DM) after gastrectomy for advanced gastric cancer. Methods This was a retrospective cohort study of consecutive patients who underwent gastrectomy for primary p-T2 or more advanced-stage gastric cancer, between April, 2008 and June, 2018. The overall survival (OS) of patients with DM and those without DM were compared using Kaplan-Meier survival analysis after adjusting for group differences using propensity score matching (PSM). Results Among the 512 patients who met the eligibility criteria, 92 (18.0%) had DM and 420 (82.0%) did not. After PSM, the subjects of this analysis were 72 patients in the DM group and 216 patients in the non-DM. OS was significantly worse in the DM group than in the non-DM group (P = 0.037). Multivariate analysis revealed that a low skeletal muscle mass index was a significant independent prognostic factor for OS in the patients with DM (hazard ratio, 2.284; 95% confidence interval, 1.005-5.189; P = 0.048). Conclusions DM in patients with advanced gastric cancer is associated with poor OS. A low skeletal muscle mass in patients with DM is a particularly poor prognostic factor for OS after surgery for gastric cancer.
引用
收藏
页码:1382 / 1391
页数:10
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