Immunologic considerations for generating memory CD8 T cells through vaccination

被引:59
作者
Butler, Noah S. [1 ]
Nolz, Jeffrey C. [1 ]
Harty, John T. [1 ,2 ,3 ]
机构
[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
[3] Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
关键词
HUMAN-IMMUNODEFICIENCY-VIRUS; IL-7; RECEPTOR-ALPHA; CLONAL EXPANSION; CUTTING EDGE; SECONDARY RESPONSES; NONLYMPHOID TISSUE; IN-VIVO; EFFECTOR; IMMUNITY; EXPRESSION;
D O I
10.1111/j.1462-5822.2011.01594.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Following infection or vaccination, naive CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naive cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
引用
收藏
页码:925 / 933
页数:9
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